Search Results

Overview

Uniprot IDQ32MZ4
Protein NameLeucine-rich repeat flightless-interacting protein 1
Gene NameLRRFIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
282 QGPTKMTKEELNALK
314 EIVANVGKREILHNT
580 KKKNKKKKSPVPVET
617 QVKSTDRKSAVEAQN
631 NEVTENPKQKIAAES
633 VTENPKQKIAAESSE
719 QSSPAEPKSEDADRC
762 HPSQTVRKALDSNSL

Function

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding

Protein Sequence

10 MTSPAAAQSR 20 EIDCLSPEAQ 30 KLAEARLAAK 40 RAARAEAREI 50 RMKELERQQK 60 EEDSERYSRR 70 SRRNTSASDE 80 DERMSVGSRG 90 SLRVEERPEK 100 DFTEKGSRNM 110 PGLSAATLAS 120 LGGTSSRRGS 130 GDTSISIDTE 140 ASIREIKELN 150 ELKDQIQDVE 160 GKYMQGLKEM 170 KDSLAEVEEK 180 YKKAMVSNAQ 190 LDNEKTNFMY 200 QVDTLKDMLL 210 ELEEQLAESR 220 RQYEEKNKEF 230 EREKHAHSIL 240 QFQFAEVKEA 250 LKQREEMLEK 260 HGIILNSEIA 270 TNGETSDTLN 280 NVGYQGPTKM 290 TKEELNALKS 300 TGDGTLGRAS 310 EVEVKNEIVA 320 NVGKREILHN 330 TEKEQHTEDT 340 VKDCVDIEVF 350 PAGENTEDQK 360 SSEDTAPFLG 370 TLAGATYEEQ 380 VQSQILESSS 390 LPENTVQVES 400 NEVMGAPDDR 410 TRTPLEPSNC 420 WSDLDGGNHT 430 ENVGEAAVTQ 440 VEEQAGTVAS 450 CPLGHSDDTV 460 YHDDKCMVEV 470 PQELETSTGH 480 SLEKEFTNQE 490 AAEPKEVPAH 500 STEVGRDHNE 510 EEGEETGLRD 520 EKPIKTEVPG 530 SPAGTEGNCQ 540 EATGPSTVDT 550 QNEPLDMKEP 560 DEEKSDQQGE 570 ALDSSQKKTK 580 NKKKKNKKKK 590 SPVPVETLKD 600 VKKELTYQNT 610 DLSEIKEEEQ 620 VKSTDRKSAV 630 EAQNEVTENP 640 KQKIAAESSE 650 NVDCPENPKI 660 KLDGKLDQEG 670 DDVQTAAEEV 680 LADGDTLDFE 690 DDTVQSSGPR 700 AGGEELDEGV 710 AKDNAKIDGA 720 TQSSPAEPKS 730 EDADRCTLPE 740 HESPSQDISD 750 ACEAESTERC 760 EMSEHPSQTV 770 RKALDSNSLE 780 NDDLSAPGRE 790 PGHFNPESRE 800 DTRGGNEKGK SKEDCTMS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.