Search Results

Overview

Uniprot IDQ32P44
Protein NameEchinoderm microtubule-associated protein-like 3
Gene NameEML3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
173 PRQKLSRKAISSANL
193 STESRGGKDPLSSPG
493 GRSPSDSKTPGRGGA

Function

Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686)

Protein Sequence

10 MDGAAGPGDG 20 PAREALQSLS 30 QRLRVQEQEM 40 ELVKAALAEA 50 LRLLRLQVPP 60 SSLQGSGTPA 70 PPGDSLAAPP 80 GLPPTCTPSL 90 VSRGTQTETE 100 VELKSSPGPP 110 GLSNGPPAPQ 120 GASEEPSGTQ 130 SEGGGSSSSG 140 AGSPGPPGIL 150 RPLQPPQRAD 160 TPRRNSSSSS 170 SPSERPRQKL 180 SRKAISSANL 190 LVRSGSTESR 200 GGKDPLSSPG 210 GPGSRRSNYN 220 LEGISVKMFL 230 RGRPITMYIP 240 SGIRSLEELP 250 SGPPPETLSL 260 DWVYGYRGRD 270 SRSNLFVLRS 280 GEVVYFIACV 290 VVLYRPGGGP 300 GGPGGGGQRH 310 YRGHTDCVRC 320 LAVHPDGVRV 330 ASGQTAGVDK 340 DGKPLQPVVH 350 IWDSETLLKL 360 QEIGLGAFER 370 GVGALAFSAA 380 DQGAFLCVVD 390 DSNEHMLSVW 400 DCSRGMKLAE 410 IKSTNDSVLA 420 VGFNPRDSSC 430 IVTSGKSHVH 440 FWNWSGGVGV 450 PGNGTLTRKQ 460 GVFGKYKKPK 470 FIPCFVFLPD 480 GDILTGDSEG 490 NILTWGRSPS 500 DSKTPGRGGA 510 KETYGIVAQA 520 HAHEGSIFAL 530 CLRRDGTVLS 540 GGGRDRRLVQ 550 WGPGLVALQE 560 AEIPEHFGAV 570 RAIAEGLGSE 580 LLVGTTKNAL 590 LRGDLAQGFS 600 PVIQGHTDEL 610 WGLCTHPSQN 620 RFLTCGHDRQ 630 LCLWDGESHA 640 LAWSIDLKET 650 GLCADFHPSG 660 AVVAVGLNTG 670 RWLVLDTETR 680 EIVSDVIDGN 690 EQLSVVRYSP 700 DGLYLAIGSH 710 DNVIYIYSVS 720 SDGAKSSRFG 730 RCMGHSSFIT 740 HLDWSKDGNF 750 IMSNSGDYEI 760 LYWDVAGGCK 770 QLKNRYESRD 780 REWATYTCVL 790 GFHVYGVWPD 800 GSDGTDINSL 810 CRSHNERVVA 820 VADDFCKVHL 830 FQYPCARAKA 840 PSRMYGGHGS 850 HVTSVRFTHD 860 DSHLVSLGGK 870 DASIFQWRVL 880 GAGGAGPAPA 890 TPSRTPSLSP ASSLDV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0030496 midbody
Cellular Component GO:1990498 mitotic spindle microtubule
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Cellular Component GO:0005876 spindle microtubule
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:1901673 regulation of mitotic spindle assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.