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Overview

Uniprot ID	Q32PZ3
Protein Name	Protein unc-45 homolog A
Gene Name	Unc45a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
279	VKKGFRGKEGAIIVD

Function

May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)

Protein Sequence

10 MTVSGPGTPE 20 PRPSDPGASS 30 AEELRKEGNE 40 LFKCGDYEGA 50 LTAYTQALSL 60 GATPQDQAIL 70 HRNRAACHLK 80 LEDYSKAESE 90 ASKAIEKDGG 100 DVKALYRRSQ 110 ALEKLGRLDQ 120 AVLDLKRCVS 130 LEPKNKVFQE 140 SLRNIGGQIQ 150 EKVRYMSSTD 160 AKVEQMFQIL 170 LDPKEKGTEK 180 KQKASQNLVV 190 LAREDAGAEK 200 IFRSNGVQLL 210 QRLLDTGETD 220 LMLAALRTLV 230 GICSEHQSRT 240 VATLSVLGTR 250 RVVSILGVEN 260 QAVSLAACHL 270 LQVMFDALKE 280 GVKKGFRGKE 290 GAIIVDPARE 300 LKVLISNLLE 310 LLTEIGVSGQ 320 GRDNALTLLI 330 KMVPRKSPKD 340 PNNSLTLWVI 350 DQGLKKILEV 360 GGSVPEAAGE 370 LTVTANSRMS 380 ASILLSKLFD 390 DLKCDAEREN 400 FHRLCENYIR 410 SWFEGQGLAG 420 KLRAIQTVSC 430 LLQGPCDAGN 440 RALELSGVME 450 SVIALCASEQ 460 EEEQLVAVEA 470 LIHAAGKAKR 480 ASFITANGVA 490 LLKDLYKGSE 500 RDSIRIRALV 510 GLCKLGSAGG 520 TDFSMKQFAE 530 GSTLKLAKQC 540 RKWLCNDQID 550 AGTRRWAVEG 560 LAYLTFDADV 570 KEEFVEDEAA 580 LKALFQLSRS 590 EERSVLFAVG 600 SALVNCTNSY 610 DYEEPDPKMV 620 ELAKYAKQHV 630 PEQHPKDKPS 640 FVRARVKKLL 650 AAGVVSAMTC 660 MVKTESPVLT 670 NSCRELLSRV 680 FLALVEEVED 690 RGTVVAQGGG 700 KALLPLALEG 710 TDVGQTKAAQ 720 ALAKLTITSN 730 PEMTFPGERI 740 YEVVRPLVSL 750 LHLSCSGLQN 760 FEALMALTNL 770 AGISERLRQK 780 ILKEKAVPMI 790 EGYMFEEHEM 800 IRRAATECMC 810 NLAMSKEVQD 820 LFEAQGNDRL 830 KLLVLYSGED 840 DELLRRAAAG 850 GLAMLTSMRP 860 SLCSRIPQVT 870 THWLEILQAL 880 LLSPNPELQH 890 RGTVVVLNMM 900 ESSKEIASTL 910 MESEVLEILS 920 VLAKGEESPV 930 TRAAAACLEK 940 AVEYRLIQPN QDGE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0051879	Hsp90 protein binding
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007517	muscle organ development
Biological Process	GO:0006457	protein folding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.