Search Results
Overview
| Uniprot ID | Q3B726 |
|---|---|
| Protein Name | DNA-directed RNA polymerase I subunit RPA43 |
| Gene Name | POLR1F |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 232 | KPKKKKKKKDPETYE |
Function
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters
Protein Sequence
10
MAAGCSEAPR
20
PAAASDGSLV
30
GQAGVLPCLE
40
LPTYAAACAL
50
VNSRYSCLVA
60
GPHQRHIALS
70
PRYLNRKRTG
80
IREQLDAELL
90
RYSESLLGVP
100
IAYDNIKVVG
110
ELGDIYDDQG
120
HIHLNIEADF
130
VIFCPEPGQK
140
LMGIVNKVSS
150
SHIGCLVHGC
160
FNASIPKPEQ
170
LSAEQWQTME
180
INMGDELEFE
190
VFRLDSDAAG
200
VFCIRGKLNI
210
TSLQFKRSEV
220
SEEVTENGTE
230
EAAKKPKKKK
240
KKKDPETYEV
250
DSGTTKLADD
260
ADDTPMEESA
270
LQNTNNANGI
280
WEEEPKKKKK
290
KKKHQEVQDQ
300
DPVFQGSDSS
310
GYQSDHKKKK
320
KKRKHSEEAE
330
FTPPLKCSPK
RKGKSNFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005736 | RNA polymerase I complex |
| Biological Process | GO:0042790 | nucleolar large rRNA transcription by RNA polymerase I |
| Biological Process | GO:0006363 | termination of RNA polymerase I transcription |
| Biological Process | GO:0006362 | transcription elongation by RNA polymerase I |
| Biological Process | GO:0006361 | transcription initiation at RNA polymerase I promoter |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.