Search Results
Overview
| Uniprot ID | Q3B8P4 |
|---|---|
| Protein Name | m7GpppX diphosphatase |
| Gene Name | Dcps |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | TAPQLKRKREPEPEE |
| 9 | ADTAPQLKRKREPEP |
Function
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway
Protein Sequence
10
MADTAPQLKR
20
KREPEPEEAE
30
TPSTEKEAGV
40
GNGTSAPVRL
50
PFSGFRVQKV
60
LRESARDKII
70
FLHGKVNEDS
80
GDTHGEDAVV
90
ILEKTPFQVE
100
HVAQLLTGNP
110
ELKLQFSNDI
120
YSTYNLFPPR
130
HLSDIKTTVV
140
YPATEKHLQK
150
YMRQDLRLIR
160
ETGDDYRSLT
170
LPYLESQSLS
180
IQWVYNILDK
190
KAEADRIVFE
200
NPDPSDGFVL
210
IPDLKWNQQQ
220
LDDLYLIAIC
230
HRRGIRSLRD
240
LTPEHLPLLR
250
NILREGQEAI
260
LKRYQVTGDR
270
LRVYLHYLPS
280
YYHLHVHFTA
290
LGFEAPGSGV
300
ERAHLLAEVI
310
ENLECDPKHY
320
QRRTLTFALR
330
TDDPLLQLLQ
KAQQP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0140932 | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| Molecular Function | GO:0000340 | RNA 7-methylguanosine cap binding |
| Biological Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.