Overview
| Uniprot ID | Q3B8Q0 |
|---|
| Protein Name | Microtubule-associated protein RP/EB family member 2 |
|---|
| Gene Name | Mapre2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
FKRMNVDKVIPVEKL |
| 212 |
AKSSPAAKPGSTPSR |
| 224 |
PSRPSSAKRASSSGS |
Function
Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity)
Protein Sequence
10
MPGPTQTLSP
20
NGENNNDIIQ
30
DNGTIIPFRK
40
HTVRGERSYS
50
WGMAVNVYST
60
SITQETMSRH
70
DIIAWVNDIV
80
SLNYTKVEQL
90
CSGAAYCQFM
100
DMLFPGCISL
110
KKVKFQAKLE
120
HEYIHNFKLL
130
QASFKRMNVD
140
KVIPVEKLVK
150
GRFQDNLDFI
160
QWFKKFYDAN
170
YDGKEYDPVE
180
ARQGQDAIPP
190
PDPGEQIFNL
200
PKKSHHANSP
210
TAGAAKSSPA
220
AKPGSTPSRP
230
SSAKRASSSG
240
SASRSDKDLE
250
TQVIQLNEQV
260
HSLKLALEGV
270
EKERDFYFGK
280
LREIELLCQE
290
HGQENDDLVQ
300
RLMEVLYASD
310
EQEGQTEEPE
320
VEEQTHDQQP
QQQEEY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035371 |
microtubule plus-end |
| Cellular Component |
GO:0005881 |
cytoplasmic microtubule |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0005815 |
microtubule organizing center |
| Cellular Component |
GO:0051233 |
spindle midzone |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0051010 |
microtubule plus-end binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0032014 |
positive regulation of ARF protein signal transduction |
| Biological Process |
GO:0120183 |
positive regulation of focal adhesion disassembly |
| Biological Process |
GO:0051549 |
positive regulation of keratinocyte migration |
| Biological Process |
GO:0035372 |
protein localization to microtubule |
| Biological Process |
GO:0031110 |
regulation of microtubule polymerization or depolymerization |
| Biological Process |
GO:0051225 |
spindle assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.