Search Results
Overview
| Uniprot ID | Q3KRA9 |
|---|---|
| Protein Name | Probable RNA/DNA demethylase ALKBH6 |
| Gene Name | ALKBH6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 238 | RAGLLLGK******* |
Function
Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids (PubMed:39845104). Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs (PubMed:35120926). May play a role in nucleic acid damage repair (PubMed:35120926)
Protein Sequence
10
MEEQDARVPA
20
LEPFRVEQAP
30
PVIYYVPDFI
40
SKEEEEYLLR
50
QVFNAPKPKW
60
TQLSGRKLQN
70
WGGLPHPRGM
80
VPERLPPWLQ
90
RYVDKVSNLS
100
LFGGLPANHV
110
LVNQYLPGEG
120
IMPHEDGPLY
130
YPTVSTISLG
140
SHTVLDFYEP
150
RRPEDDDPTE
160
QPRPPPRPTT
170
SLLLEPRSLL
180
VLRGPAYTRL
190
LHGIAAARVD
200
ALDAASSPPN
210
AAACPSARPG
220
ACLVRGTRVS
230
LTIRRVPRVL
RAGLLLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.