Overview
| Uniprot ID | Q3KRE0 |
|---|
| Protein Name | ATPase family AAA domain-containing protein 3A |
|---|
| Gene Name | Atad3a |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 423 |
LRKRATEKISEDLRA |
Function
Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR)
Protein Sequence
10
MSWLFGIKGP
20
KGEGTGPPLP
30
LPPAQPGAES
40
GGDRGAGDRP
50
SPKDKWSNFD
60
PTGLERAAKA
70
ARELEHSRHA
80
KEALNLAQMQ
90
EQTLQLEQQS
100
KLKEYEAAVE
110
QLKSEQIRVQ
120
AEERRKTLNE
130
ETRQHQARAQ
140
YQDKLARQRY
150
EDQLKQQQLL
160
NEENLRKQEE
170
SVQKQEAIRR
180
ATVEREMELR
190
HKNEMLRVEA
200
EARARAKADR
210
ENADIIREQI
220
RLKAAEHRQT
230
ILESIRTAGT
240
LFGEGFRAFV
250
TDWDKVTATV
260
AGLTLLAVGV
270
YSAKNATSVA
280
GRYIEARLGK
290
PSLVRETSRI
300
SVLEALRHPI
310
QVSRRLVSRP
320
QDALEGVILS
330
PSLEARVRDI
340
AIATRNTKKN
350
KSLYRNVLMY
360
GPPGTGKTLF
370
AKKLALHSGM
380
DYAIMTGGDV
390
APMGREGVTA
400
MHKVFDWAST
410
SRRGLLLFVD
420
EADAFLRKRA
430
TEKISEDLRA
440
TLNAFLHRTG
450
QHSNKFMLVL
460
ASNQPEQFDW
470
AINDRIDEMV
480
CFALPQREER
490
ERLVRMYFDK
500
YVLKPATEGK
510
QRLKVAQFDY
520
GKKCSEVAQL
530
TAGMSGREIA
540
QLAVAWQAMA
550
YSSEDGVLTE
560
AMMDARVQDA
570
VQQHQQKMQW
580
LKVERPDSEA
590
SKPPHPSLLS
C
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0042645 |
mitochondrial nucleoid |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0030291 |
protein serine/threonine kinase inhibitor activity |
| Biological Process |
GO:0140374 |
antiviral innate immune response |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0140468 |
HRI-mediated signaling |
| Biological Process |
GO:0007005 |
mitochondrion organization |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:1903898 |
negative regulation of PERK-mediated unfolded protein response |
| Biological Process |
GO:0001558 |
regulation of cell growth |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.