Search Results
Overview
| Uniprot ID | Q3KRE8 |
|---|---|
| Protein Name | Tubulin beta-2B chain |
| Gene Name | Tubb2b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 58 | YNEATGNKYVPRAIL |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:19465910). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity)
Protein Sequence
10
MREIVHIQAG
20
QCGNQIGAKF
30
WEVISDEHGI
40
DPTGSYHGDS
50
DLQLERINVY
60
YNEATGNKYV
70
PRAILVDLEP
80
GTMDSVRSGP
90
FGQIFRPDNF
100
VFGQSGAGNN
110
WAKGHYTEGA
120
ELVDSVLDVV
130
RKESESCDCL
140
QGFQLTHSLG
150
GGTGSGMGTL
160
LISKIREEYP
170
DRIMNTFSVM
180
PSPKVSDTVV
190
EPYNATLSVH
200
QLVENTDETY
210
CIDNEALYDI
220
CFRTLKLTTP
230
TYGDLNHLVS
240
ATMSGVTTCL
250
RFPGQLNADL
260
RKLAVNMVPF
270
PRLHFFMPGF
280
APLTSRGSQQ
290
YRALTVPELT
300
QQMFDSKNMM
310
AACDPRHGRY
320
LTVAAIFRGR
330
MSMKEVDEQM
340
LNVQNKNSSY
350
FVEWIPNNVK
360
TAVCDIPPRG
370
LKMSATFIGN
380
STAIQELFKR
390
ISEQFTAMFR
400
RKAFLHWYTG
410
EGMDEMEFTE
420
AESNMNDLVS
430
EYQQYQDATA
440
DEQGEFEEEE
GEDEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:1990403 | embryonic brain development |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:1902669 | positive regulation of axon guidance |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.