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Overview

Uniprot IDQ3LRZ1
Protein NameCREB-regulated transcription coactivator 2
Gene NameCrtc2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
56 STRLQAQKLRLAYTR

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity)

Protein Sequence

10 MATSGANGPG 20 SATASASNPR 30 KFSEKIALQK 40 QRQAEETAAF 50 EEVMMDIGST 60 RLQAQKLRLA 70 YTRSSHYGGS 80 LPNVNQIGCG 90 LAEFQSPLHS 100 PLDSSRSTRH 110 HGLVERVQRD 120 PRRMVSPLRR 130 YPRHIDSSPY 140 SPAYLSPPPE 150 SGWRRMMPWG 160 NLPAEKGQLF 170 RLPSALNRTS 180 SDSALHTSVM 190 NPNPQDTYPG 200 PTPPSVLPSR 210 RGGFLDGEMD 220 AKVPAIEENL 230 VDDKHLLKPW 240 DAKKLSSSSS 250 RPRSCEVPGI 260 NIFPSPDQPA 270 NVPVLPPAMS 280 TGGSLPDLTN 290 LHFPPPLPTP 300 LDPEETVYPS 310 LSGGNSTTNL 320 THTMTHLGIS 330 GGLGLGPSYD 340 VPGLHSPLSH 350 PSLQSSLSNP 360 NLQASLSSPQ 370 PQLQGSHSHP 380 SLPASSLAHH 390 ALPTTSLGHP 400 SLSAPALSSS 410 SSSSSTSSPV 420 LSAPPYPAST 430 PGASPRHRRV 440 PLSPLSLPAG 450 PADARRSQQQ 460 LPKQFSPTMS 470 PTLSSITQGV 480 PLDTSKLPTD 490 QRLPPYPYSP 500 PSLVIPSHPP 510 TPKSLQQLPS 520 QACLVQPSGG 530 QPPGRQPHYG 540 TLYPPGSSGH 550 GQQPYHRPIN 560 DFSLGNLEQF 570 NMESPSTSLV 580 LDPPAFSEGP 590 GFLGSEGSVS 600 GPQDSHVLNH 610 QNLTHCSRHG 620 SGPNIILTGD 630 SSPGFSKEIA 640 AALAGVPGFE 650 VSASGLELGL 660 GLEDELRMEP 670 LGLEGLTMLS 680 DPCALLPDPA 690 VEDSFRSDRL Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008140 cAMP response element binding protein binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051289 protein homotetramerization

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.