Search Results
Overview
| Uniprot ID | Q3MHD2 |
|---|---|
| Protein Name | Protein LSM12 |
| Gene Name | LSM12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | SQAQQPQKEAALSS* |
| 86 | LASLNVSKLASKART |
Function
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892)
Protein Sequence
10
MAAPPGEYFS
20
VGSQVSCRTC
30
QEQRLQGEVV
40
AFDYQSKMLA
50
LKCPSSSGKP
60
NHADILLINL
70
QYVSEVEIIN
80
DRTETPPPLA
90
SLNVSKLASK
100
ARTEKEEKLS
110
QAYAISAGVS
120
LEGQQLFQTI
130
HKTIKDCKWQ
140
EKNIVVMEEV
150
VITPPYQVEN
160
CKGKEGSALS
170
HVRKIVEKHF
180
RDVESQKILQ
190
RSQAQQPQKE
AALSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0003723 | RNA binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.