Overview
| Uniprot ID | Q3MHS2 |
|---|
| Protein Name | Zinc finger protein 830 |
|---|
| Gene Name | Znf830 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 102 |
GTAPQPTKRKTTDVE |
Function
May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity)
Protein Sequence
10
MASSTSARTP
20
AGKRVVNQEE
30
LRRLMKEKQR
40
LSTNRKRIES
50
PFAKYNRLGQ
60
LSCALCNTPV
70
KSELLWQTHV
80
LGKQHRERVA
90
ELKGAKGATQ
100
GPSAGTAPQP
110
TKRKTTDVES
120
QDAKKAKASV
130
DQVQPSTSAS
140
SANFEKSGKE
150
ATRVASSKTG
160
LGLLPDYEEE
170
EEEEEEEELG
180
GGEERRDSSK
190
HLPDAQGREH
200
SLASPRETTS
210
NVLPNDPFNT
220
NPPKAPLVPH
230
SGSIEKAEIH
240
EKVVERRENT
250
AEALPEGFFD
260
DPEVDAKVRK
270
VDAPKDQMDK
280
EWDEFQKAMR
290
QVNTISEAIV
300
AEEDEEGRLD
310
RQIGEIDEQI
320
ECYRRVEKLR
330
NRQDEIKNKL
340
KEVLTIKELQ
350
KKEEENVDSD
360
DEGELQDLLS
370
QDWRVKGALL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003676 |
nucleic acid binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0044773 |
mitotic DNA damage checkpoint signaling |
| Biological Process |
GO:0033314 |
mitotic DNA replication checkpoint signaling |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0033260 |
nuclear DNA replication |
| Biological Process |
GO:0001541 |
ovarian follicle development |
| Biological Process |
GO:0001546 |
preantral ovarian follicle growth |
| Biological Process |
GO:0006396 |
RNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.