Search Results
Overview
| Uniprot ID | Q3MHS7 |
|---|---|
| Protein Name | GDP-mannose 4,6 dehydratase |
| Gene Name | Gmds |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | SGDGEMGKLRKVALI |
Function
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose
Protein Sequence
10
MAHAPASCRR
20
YPGSGDGEMG
30
KLRKVALITG
40
ITGQDGSYLA
50
EFLLEKGYEV
60
HGIVRRSSSF
70
NTGRIEHLYK
80
NPQAHIEGNM
90
KLHYGDLTDS
100
TCLVKIINEV
110
KPTEIYNLGA
120
QSHVKISFDL
130
AEYTADVDGV
140
GTLRLLDAIK
150
TCGLINSVKF
160
YQASTSELYG
170
KVQEIPQKET
180
TPFYPRSPYG
190
AAKLYAYWIV
200
VNFREAYNLF
210
AVNGILFNHE
220
SPRRGANFVT
230
RKISRSVAKI
240
YLGQLECFSL
250
GNLDAKRDWG
260
HAKDYVEAMW
270
LMLQNDEPED
280
FVIATGEVHS
290
VREFVEKSFM
300
HIGKTIVWEG
310
KNENEVGRCK
320
ETGKIHVTVD
330
LKYYRPTEVD
340
FLQGDCSKAQ
350
QKLNWKPRVA
360
FDELVREMVQ
370
ADVELMRTNP
NA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008446 | GDP-mannose 4,6-dehydratase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070401 | NADP+ binding |
| Biological Process | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process |
| Biological Process | GO:0019673 | GDP-mannose metabolic process |
| Biological Process | GO:0007219 | Notch signaling pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.