Search Results
Overview
| Uniprot ID | Q3MID3 |
|---|---|
| Protein Name | ADP-ribosylation factor GTPase-activating protein 2 |
| Gene Name | Arfgap2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 428 | RQKFAGAKAISSDMF |
Function
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)
Protein Sequence
10
MAAGPSKSEI
20
QTLFKRLRAI
30
PTNKACFDCG
40
AKSPSWASIT
50
YGVFLCIDCS
60
GVHRSLGVHL
70
SFIRSTELDS
80
NWSWLQLRCM
90
QVGGNANATA
100
FFRQHGCLAN
110
DANTKYNSRA
120
AQMYREKIRQ
130
LGSTALARHG
140
TDLWIDNMNS
150
APSHSPEKKD
160
SDFFTEHTQA
170
PAWDTAATDP
180
SGTQQPALPS
190
ESSSLAQPEP
200
GPNTDLLGTS
210
PQASLELKSS
220
IIGKKKPAAA
230
KKGLGAKKGL
240
GAQKVSNQSF
250
TEIERQAQVA
260
EKLREQQAAD
270
AKKQAEESMV
280
ASMRLAYQEL
290
QIDRKKEEKK
300
LQNLEGKKRE
310
QAERLGMGLV
320
SRSSISHSVL
330
SEMQMIEQET
340
PLSAKSSRSQ
350
LDLFDDVGTF
360
ASGPPKYKDN
370
PFSLGETFGS
380
RWDSDAAWGM
390
DRVEEKEPEV
400
TISSIRPISE
410
RTTSRREVES
420
RISGLESSEA
430
RQKFAGAKAI
440
SSDMFFGREV
450
DSEYEARSRL
460
QQLSGSSAIS
470
SSDLFGDVDG
480
AHGGGTVSLG
490
NVLPTADIAQ
500
FKQGVKSVAG
510
KMAVLANGVM
520
NSLQDRYGSY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0048205 | COPI coating of Golgi vesicle |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.