Search Results
Overview
| Uniprot ID | Q3MIE4 |
|---|---|
| Protein Name | NADPH-dependent quinone oxidoreductase VAT1 |
| Gene Name | Vat1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 288 | AKGYHLLKPMGKVVT |
| 393 | QEKKNIGKVLLVPGP |
Function
Multifunctional protein with enzymatic and transport activities. Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear. Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes (By similarity). Could regulate mitochondrial fusion through its interaction with mitofusins (PubMed:17105775)
Protein Sequence
10
MSAEREATEA
20
ATVAAAAEAR
30
AETGAGEGAP
40
SQPPTVEVAS
50
DPQPPPAPEA
60
SASASAPPLR
70
CLVLTGFGGY
80
DKVKLQSRPA
90
VPPAPGPGQV
100
TLRVRACGLN
110
FADLMGRQGL
120
YDRLPPLPVT
130
PGMEGAGVVV
140
AVGEGVSDRK
150
AGDRVMVLNR
160
SGMWQEEVTV
170
PSAQTFLMPE
180
AMTFEEAAAL
190
LVNYITAYMV
200
LFDFGNLRPG
210
HSVLVHMAAG
220
GVGMAALQLC
230
RTVENVTVFG
240
TASASKHEVL
250
KENGVTHPID
260
YHTTDYVDEI
270
KKISPKGVDI
280
VMDPLGGSDT
290
AKGYHLLKPM
300
GKVVTYGMAN
310
LLTGPKRNLM
320
AMARTWWNQF
330
SVTALQLLQA
340
NRAVCGFHLG
350
YLDGEVELVS
360
RVVTHLLALY
370
NQGHIKPRID
380
SVWPFEKVAD
390
AMRQMQEKKN
400
IGKVLLVPGP
EKET
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0008753 | NADPH dehydrogenase (quinone) activity |
| Molecular Function | GO:0120014 | phospholipid transfer activity |
| Molecular Function | GO:0003960 | quinone reductase (NADPH) activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0120010 | intermembrane phospholipid transfer |
| Biological Process | GO:0010637 | negative regulation of mitochondrial fusion |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.