Overview
| Uniprot ID | Q3S4A5 |
|---|
| Protein Name | ADP-ribosylation factor GTPase-activating protein 1 |
|---|
| Gene Name | Arfgap1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 226 |
SKFASAAKEGATKFG |
Function
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine
Protein Sequence
10
MASPRTRKVL
20
KEVRAQDENN
30
VCFECGAFNP
40
QWVSVTYGIW
50
ICLECSGRHR
60
GLGVHLSFVR
70
SVTMDKWKDI
80
ELEKMKAGGN
90
AKFREFLEAQ
100
DDYEPSWSLQ
110
DKYSSRAAAL
120
FRDKVATLAE
130
GKEWSLESSP
140
AQNWTPPQPK
150
TLQFTAHRPA
160
GQPQNVTTSG
170
DKAFEDWLND
180
DLGSYQGAQE
190
NRYVGFGNTV
200
PPQKREDDFL
210
NSAMSSLYSG
220
WSSFTTGASK
230
FASAAKEGAT
240
KFGSQASQKF
250
WGYKQQSEPA
260
SELGHSLNEN
270
VLKPAQEKGV
280
GSKGWRDVTT
290
FFSGKAEDTS
300
DRPLEGHSYQ
310
NSSGDNSQNS
320
TIDQSFWETF
330
GSAEPPKAKS
340
PSSDSWTCAD
350
ASTGRRSSDS
360
WDIWGSGSAS
370
NNKNSNSDGW
380
ESWEGASGEG
390
RAKATKKAAP
400
STAADEGWDN
QNW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.