Overview
| Uniprot ID | Q3SYG4 |
|---|
| Protein Name | Protein PTHB1 |
|---|
| Gene Name | BBS9 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 390 |
VEMKELQKIIKDVNK |
Function
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization
Protein Sequence
10
MSLFKARDWW
20
STILGDKEEF
30
DQGCLCLANV
40
DNSGNGQDKI
50
IVGSFMGYLR
60
IFSPHPAKTG
70
DGAQAEDLLL
80
EVDLRDPVLQ
90
VEVGKFVSGT
100
EMLHLAVLHS
110
RKLCVYSVSG
120
TLGNVEHGNQ
130
CQMKLMYEHN
140
LQRTACNMTY
150
GSFGGVKGRD
160
LICIQSMDGM
170
LMVFEQESYA
180
FGRFLPGFLL
190
PGPLAYSSRT
200
DSFLTVSSCQ
210
QVESYKYQVL
220
AFATDADKRQ
230
ETEQQKLGSG
240
KRLVVDWTLN
250
IGEQALDICI
260
VSFNQSASSV
270
FVLGERNFFC
280
LKDNGQIRFM
290
KKLDWSPSCF
300
LPYCSVSEGT
310
INTLIGNHNN
320
MLHIYQDVTL
330
KWATQLPHIP
340
VAVRVGCLHD
350
LKGVIVTLSD
360
DGHLQCSYLG
370
TDPSLFQAPN
380
VQSRELNYDE
390
LDVEMKELQK
400
IIKDVNKSQG
410
VWPMTEREDD
420
LNVSVVVSPN
430
FDSVSQATDV
440
EVGTDLVPSV
450
TVKVTLQNRV
460
ILQKAKLSVY
470
VQPPLELTCD
480
QFTFEFMTPD
490
LTRTVSFSVY
500
LKRSYTPSEL
510
EGNAVVSYSR
520
PTDRNPDGIP
530
RVIQCKFRLP
540
LKLICLPGQP
550
SKTASHKITI
560
DTNKSPVSLL
570
SLFPGFASQS
580
DDDQVNVMGF
590
HFLGGARITV
600
LASKTSQRYR
610
IQSEQFEDLW
620
LITNELILRL
630
QEYFEKQGVK
640
DFACSFSGSI
650
PLQEYFELID
660
HHFELRINGE
670
KLEELLSERA
680
VQFRAIQRRL
690
LARFKDKTPA
700
PLQHLDTLLD
710
GTYKQVIALA
720
DAVEENQGNL
730
FQSFTRLKSA
740
THLVILLIAL
750
WQKLSADQVA
760
ILEAAFLPLQ
770
EDTQELGWEE
780
TVDAAISHLL
790
KTCLSKSSKE
800
QALNLNSQLN
810
IPKDTSQLKK
820
HITLLCDRLS
830
KGGRLCLSTD
840
AAAPQTMVMP
850
GGCTTIPESD
860
LEERSVEQDS
870
TELFTNHRHL
880
TAETPRPEVS
PLQGVSE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034464 |
BBSome |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0060170 |
ciliary membrane |
| Cellular Component |
GO:0097542 |
ciliary tip |
| Cellular Component |
GO:0035869 |
ciliary transition zone |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0000242 |
pericentriolar material |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0045444 |
fat cell differentiation |
| Biological Process |
GO:0061512 |
protein localization to cilium |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0007601 |
visual perception |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.