Search Results
Overview
| Uniprot ID | Q3T1K5 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha-2 |
| Gene Name | Capza2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 268 | QLPVTRTKIDWNKIL |
| 278 | WNKILSYKIGKEMQN |
| 97 | PKNRICFKFDHLRKE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity)
Protein Sequence
10
MADLEEQLSD
20
EEKVRIAAKF
30
IIHAPPGEFN
40
EVFNDVRLLL
50
NNDNLLREGA
60
AHAFAQYNLD
70
QFTPVKIEGY
80
EDQVLITEHG
90
DLGNGKFLDP
100
KNRICFKFDH
110
LRKEATDPRP
120
YEAENAIESW
130
RTSVETALRA
140
YVKEHYPNGV
150
CTVYGKKVDG
160
QQTIIACIES
170
HQFQAKNFWN
180
GRWRSEWKFT
190
VTPSTTQVVG
200
ILKIQVHYYE
210
DGNVQLVSHK
220
DIQDSLTVSN
230
EVQTAKEFIK
240
IVEAAENEYQ
250
TAISENYQTM
260
SDTTFKALRR
270
QLPVTRTKID
280
WNKILSYKIG
KEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.