Search Results

Overview

Uniprot IDQ3T8J9
Protein NameGON-4-like protein
Gene NameGON4L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
133 TGSKRGKKMTLRPGP

Function

Acts as a key transcription regulator of histones (PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (By similarity). Required for B-cell lymphopoiesis (By similarity)

Protein Sequence

10 MLPCKKRRTT 20 VTESLQHKGN 30 QEENNVDLES 40 AVKPESDQVK 50 DLSSVSLSWD 60 PSHGRVAGFE 70 VQSLQDAGNQ 80 LGMEDTSLSS 90 GMLTQNTNVP 100 ILEGVDVAIS 110 QGITLPSLES 120 FHPLNIHIGK 130 GKLHATGSKR 140 GKKMTLRPGP 150 VTQEDRCDHL 160 TLKEPFSGEP 170 SEEVKEEGGK 180 PQMNSEGEIP 190 SLPSGSQSAK 200 PVSQPRKSTQ 210 PDVCASPQEK 220 PLRTLFHQPE 230 EEIEDGGLFI 240 PMEEQDNEES 250 EKRRKKKKGT 260 KRKRDGRGQE 270 GTLAYDLKLD 280 DMLDRTLEDG 290 AKQHNLTAVN 300 VRNILHEVIT 310 NEHVVAMMKA 320 AISETEDMPM 330 FEPKMTRSKL 340 KEVVEKGVVI 350 PTWNISPIKK 360 ANEIKPPQFV 370 DIHLEEDDSS 380 DEEYQPDDEE 390 EDETAEESLL 400 ESDVESTASS 410 PRGAKKSRLR 420 QSSEMTETDE 430 ESGILSEAEK 440 VTTPAIRHIS 450 AEVVPMGPPP 460 PPKPKQTRDS 470 TFMEKLHAVD 480 EELASSPVCM 490 DSFQPMDDSL 500 IAFRTRSKMP 510 LKDVPLGQLE 520 AELQAPDITP 530 DMYDPNTADD 540 EDWKMWLGGL 550 MNDDVGNEDE 560 ADDDDDPEYN 570 FLEDLDEPDT 580 EDFRTDRAVR 590 ITKKEVNELM 600 EELFETFQDE 610 MGFSNMEDDG 620 PEEEECVAEP 630 RPNFNTPQAL 640 RFEEPLANLL 650 NEQHRTVKEL 660 FEQLKMKKSS 670 AKQLQEVEKV 680 KPQSEKVHQT 690 LILDPAQRKR 700 LQQQMQQHVQ 710 LLTQIHLLAT 720 CNPNLNPEAT 730 TTRIFLKELG 740 TFAQSSIALH 750 HQYNPKFQTL 760 FQPCNLMGAM 770 QLIEDFSTHV 780 SIDCSPHKTV 790 KKTANEFPCL 800 PKQVAWILAT 810 SKVFMYPELL 820 PVCSLKAKNP 830 QDKIVFTKAE 840 DNLLALGLKH 850 FEGTEFPNPL 860 ISKYLLTCKT 870 AHQLTVRIKN 880 LNMNRAPDNI 890 IKFYKKTKQL 900 PVLGKCCEEI 910 QPHQWKPPIE 920 REEHRLPFWL 930 KASLPSIQEE 940 LRHMADGARE 950 VGNMTGTTEI 960 NSDRSLEKDN 970 LELGSESRYP 980 LLLPKGVVLK 990 LKPVATRFPR 1000 KAWRQKRSSV 1010 LKPLLIQPSP 1020 SLQPSFNPGK 1030 TPARSTHSEA 1040 PPSKMVLRIP 1050 HPIQPATVLQ 1060 TVPGVPPLGV 1070 SGGESFESPA 1080 ALPAVPPEAR 1090 TSFPLSESQT 1100 LLSSAPVPKV 1110 MLPSLAPSKF 1120 RKPYVRRRPS 1130 KRRGVKASPC 1140 MKPAPVIHHP 1150 ASVIFTVPAT 1160 TVKIVSLGGG 1170 CNMIQPVNAA 1180 VAQSPQTIPI 1190 TTLLVNPTSF 1200 PCPLNQSLVA 1210 SSVSPLIVSG 1220 NSVNLPIPST 1230 PEDKAHVNVD 1240 IACAVADGEN 1250 AFQGLEPKLE 1260 PQELSPLSAT 1270 VFPKVEHSPG 1280 PPLADAECQE 1290 GLSENSACRW 1300 TVVKTEEGRQ 1310 ALEPLPQGIQ 1320 ESLNNPTPGD 1330 LEEIVKMEPE 1340 EAREEISGSP 1350 ERDICDDIKV 1360 EHAVELDTGA 1370 PSEELSSAGE 1380 VTKQTVLQKE 1390 EERSQPTKTP 1400 SSSQEPPDEG 1410 TSGTDVNKGS 1420 SKNALSSMDP 1430 EVRLSSPPGK 1440 PEDSSSVDGQ 1450 SVGTPVGPET 1460 GGEKNGPEEE 1470 EEEDFDDLTQ 1480 DEEDEMSSAS 1490 EESVLSVPEL 1500 QETMEKLTWL 1510 ASERRMSQEG 1520 ESEEENSQEE 1530 NSEPEEEEEE 1540 EAEGMESLQK 1550 EDEMTDEAVG 1560 DSAEKPPTFA 1570 SPETAPEVET 1580 SRTPPGESIK 1590 AAGKGRNNHR 1600 ARNKRGSRAR 1610 ASKDTSKLLL 1620 LYDEDILERD 1630 PLREQKDLAF 1640 AQAYLTRVRE 1650 ALQHIPGKYE 1660 DFLQVIYEFE 1670 SSTQRRTAVD 1680 LYKSLQILLQ 1690 DWPQLLKDFA 1700 AFLLPEQALA 1710 CGLFEEQQAF 1720 EKSRKFLRQL 1730 EICFAENPSH 1740 HQKIIKVLQG 1750 CADCLPQEIT 1760 ELKTQMWQLL 1770 KGHDHLQDEF 1780 SIFFDHLRPA 1790 ASRMGDFEEI 1800 NWTEEKEYEF 1810 DGFEEVALPD 1820 VEEEEEPPKI 1830 PTASKNKRKK 1840 EIGVQNHDKE 1850 TEWPDGAKDC 1860 ACSCHEGGPD 1870 SKLKKSKRRS 1880 CSHCSSKVCD 1890 SKSYKSKEPH 1900 ELVGSSPHRE 1910 ASPMPGAKEA 1920 GQGKDMMEEE 1930 APEERESTEA 1940 TQSRTVRTTR 1950 KGEMPVSAGL 1960 AVGSTLPSPR 1970 EVTVTERLLL 1980 DGPPPHSPET 1990 PQFPPTTGAV 2000 LYTVKRNQVG 2010 PEVRSCPKAS 2020 PRLQKEREGQ 2030 KAVSESEALM 2040 LVWDASETEK 2050 LPGTVEPPAS 2060 FLSPVSSKTR 2070 DAGRRHVSGK 2080 PDTQERWLPS 2090 SRARVKTRDR 2100 TCPVHESPSG 2110 IDTSETSPKA 2120 PRGGLAKDSG 2130 TQAKGPEGEQ 2140 QPKAAEATVC 2150 ANNSKVSSTG 2160 EKVVLWTREA 2170 DRVILTMCQE 2180 QGAQPQTFNI 2190 ISQQLGNKTP 2200 AEVSHRFREL 2210 MQLFHTACEA 2220 SSEDEDDATS 2230 TSNADQLSDH 2240 GDLLSEEELD E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.