Search Results
Overview
| Uniprot ID | Q3TC72 |
|---|---|
| Protein Name | Oxaloacetate tautomerase Fahd2a, mitochondrial |
| Gene Name | Fahd2a |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EQNVRVPKSPIIFSK |
| 202 | DWQMRNGKQWLLGKT |
Function
Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition
Protein Sequence
10
MLGFGRRRLF
20
SALLQVQKRP
30
CQPSRNMRLV
40
QFQAPHLEEP
50
HLGLESGVGG
60
GVVDLNAFDS
70
TLPKTMVQFL
80
EQGETTLSVA
90
RRALATQLPV
100
IPRSQVTFLA
110
PVTRPDKVIC
120
VGLNYADHCQ
130
EQNVRVPKSP
140
IIFSKFSSSI
150
VGPYDEIILP
160
PESKEVDWEV
170
EMAVVIGKKG
180
KHIKATDVMA
190
HVAGFTVAHD
200
VSARDWQMRN
210
GKQWLLGKTF
220
DTFCPLGPAL
230
VTKDTIADPH
240
NLKICCRVNG
250
EVVQSSNTNQ
260
MVFKTEYLIA
270
WVSQFVTLYP
280
GDLLLTGTPP
290
GVGMFRKPPV
300
FLKKGDEVQC
310
EIEELGVIIN
KVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050163 | oxaloacetate tautomerase activity |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.