Search Results
Overview
| Uniprot ID | Q3TJD7 |
|---|---|
| Protein Name | PDZ and LIM domain protein 7 |
| Gene Name | Pdlim7 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | GFRLQGGKDFNVPLS |
Function
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)
Protein Sequence
10
MDSFKVVLEG
20
PAPWGFRLQG
30
GKDFNVPLSI
40
SRLTPGGKAA
50
QAGVAVGDWV
60
LNIDGENAGS
70
LTHIEAQNKI
80
RACGERLSLG
90
LSRAQPVQSK
100
PQKALTPPAD
110
PPRYTFAPSA
120
SLNKTARPFG
130
APPPTDSTLR
140
QNGQLLRQPV
150
PDASKQRLME
160
DTEDWRPRPG
170
TGQSRSFRIL
180
AHLTGTEFMQ
190
DPDEEFMKKS
200
SQVPRTEAPA
210
PASTIPQESW
220
PGPTTPSPTS
230
RPPWAVDPAF
240
AERYAPDKTS
250
TVLTRHSQPA
260
TPTPLQNRTS
270
IVQAAAGGGT
280
GGGSNNGKTP
290
VCHQCHKIIR
300
GRYLVALGHA
310
YHPEEFVCSQ
320
CGKVLEEGGF
330
FEEKGAIFCP
340
SCYDVRYAPN
350
CAKCKKKITG
360
EIMHALKMTW
370
HVHCFTCAAC
380
KTPIRNRAFY
390
MEEGAPYCER
400
DYEKMFGTKC
410
RGCDFKIDAG
420
DRFLEALGFS
430
WHDTCFVCAI
440
CQINLEGKTF
450
YSKKDKPLCK
SHAFSHV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051371 | muscle alpha-actinin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.