Search Results

Overview

Uniprot IDQ3TL44
Protein NameNLR family member X1
Gene NameNlrx1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
301 TISRIPSKYVGRYGE

Function

Participates in antiviral signaling (PubMed:35651602). Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (PubMed:35651602). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (PubMed:35651602)

Protein Sequence

10 MRWGCHLPRT 20 SWGSGLGRTP 30 QLPDEHISFL 40 IQWSWPFKGV 50 HPLRPPRAFI 60 RYHGNSADSA 70 PPPGRHGQLF 80 RSISATEAIQ 90 RHRRNLTEWF 100 SRLPREERQF 110 GPTFALDTVH 120 VDPVIRESTP 130 DELLRPSTEL 140 ATGHQQTQAG 150 LPPLALSQLF 160 DPDSCGRRVQ 170 TVVLYGTVGT 180 GKSTLVRKMV 190 LDWCYGRLPA 200 FELLIPFSCE 210 DLSSLGSTPA 220 SLCQLVTQRY 230 TPLKEVLPLM 240 TAAGSRLLFV 250 LHGLERLNLD 260 FRLAGTGLCS 270 DPEEPGPPAA 280 IIVNLLRKYM 290 LPEASILVTT 300 RPSTISRIPS 310 KYVGRYGEIC 320 GFSDTNLQKL 330 YFQLRLNQPD 340 CGYGAGGASV 350 SVTPAQRDNL 360 IQMLSRNLEG 370 HHQIAAACFL 380 PSYCWLVCAT 390 LHFLHAPTPA 400 GQTLTSIYTS 410 FLRLNFSGET 420 LDSTHTSNLS 430 LMSYAARTMG 440 KLAYEGVSSR 450 KTYFSEEDVR 460 GCLEAGIKTE 470 EEFQLLQIFR 480 RDALRFFLAP 490 CVEPGHLGTF 500 VFTVPAMQEY 510 LAALYIVLGL 520 RKTALQRVGK 530 EVVEFVGRVG 540 EDVSLVLGIV 550 AKLLPLRILP 560 LLFNLLKVVP 570 RVFGRMVSKS 580 REAVAQAMVL 590 EMFREEDYYN 600 DDVLDQMGAS 610 ILGVEGPRRH 620 PDEPSEDEVF 630 ELFPMFMGGL 640 LSAHNRAVLA 650 QLGCPIKNLD 660 ALENAQAIKK 670 KLGKLGRQVL 680 PPSELLDHLF 690 FHYEFQNQRF 700 SAEVLGSLRQ 710 LNLAGVRMTP 720 LKCTVVASVL 730 GSGRHPLDEV 740 NLASCQLDPA 750 GLHTLMPVLL 760 RARKLGLQLN 770 NLGPEACRDL 780 RDLLLHDQCQ 790 ITTLRLSNNP 800 LTAAGVGLLM 810 DGLAGNTSVT 820 HLSLLHTDLG 830 DEGLELLAAQ 840 LDRNKQLQEL 850 NVAYNGAGDT 860 VALALAKAAR 870 EHPSLELLHL 880 YFNELSSEGR 890 QVLRDLGGSG 900 EGGARVVASL 910 TEGTAVSEYW 920 SVILSEVQRN 930 VHSWDPLRVQ 940 RHLKLLLRDL 950 EDSRGATLNP 960 WRKAQLLRVE 970 GEVKTLLEQL GGSGH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005524 ATP binding
Biological Process GO:0045087 innate immune response
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0045824 negative regulation of innate immune response
Biological Process GO:0032688 negative regulation of interferon-beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0039536 negative regulation of RIG-I signaling pathway

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.