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Overview

Uniprot ID	Q3U0M1
Protein Name	Trafficking protein particle complex subunit 9
Gene Name	Trappc9
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
174	ATDKSGDKIPLLCVP

Function

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi

Protein Sequence

10 MSVPDYMQCA 20 EDHQTLLVVV 30 QAVGIVSEEN 40 FFRIYKRICS 50 VSQLSVRDTQ 60 RALFIRYRHH 70 YPPENNEWGD 80 FQTHRKVVGL 90 ITITDCFSPK 100 DWPQTFEKFH 110 VQKEIYGSTL 120 YDSRLFVFGL 130 QGDVAEQPRP 140 DVAFYPNYDD 150 CDSVEKRIED 160 FIESLFIVLE 170 SKRLDRATDK 180 SGDKIPLLCV 190 PFEKKDFVGL 200 DTDSRHYKKR 210 CQGRMRKHVG 220 DLCLQAGMLQ 230 DALVHYHMSV 240 ELLRSVNDFL 250 WLGAALEGLC 260 SASVIYHYPG 270 GTGGKTGARR 280 LQGSSLPSEA 290 ANRHRPGAQE 300 VLIDPGALTT 310 NGINPDTSTE 320 IGRAKNCLSP 330 EDIIDKYKEA 340 ISYYSKYKNA 350 GVIELEACVK 360 AVRVLAIQKR 370 GMEASEFLQN 380 AVYINLRQLS 390 EEEKIQRYSI 400 LSELYELIGF 410 HRKSAFFKRV 420 AAMQCVAPSI 430 AEPGWRACYK 440 LLLETLPGYS 450 LSLDPKDFSK 460 GTHRGWAAVQ 470 MRLLHELVYA 480 SRRMGNPALS 490 VRHLSFLLQT 500 MLDFLSDQEK 510 KDVTQSLENY 520 TAKCPGTMEP 530 ITLPDGLTLP 540 PVPFTKLPIV 550 RCVKLLSLPT 560 SLRPHKVKSL 570 LGQSMSTKSP 580 FIYSPIIAHN 590 RGEERNKKID 600 FQWVQGDVCE 610 VQLMVYNPMP 620 FELRVENMGL 630 LTSGVEFESL 640 PAALSLPAES 650 GLYPVTLVGV 660 PQTTGMITVN 670 GYHTTVFGVF 680 SDCLLDNLPG 690 LKTGGSTVEV 700 IPALPRLQIS 710 TSLPRSARSL 720 QPSAGDEIAT 730 NVSVQLYNGE 740 TQQLAVTLEN 750 IGLEPLEQLE 760 VTSKLLTTKE 770 KLYGDFLSWK 780 LEETLAQFPL 790 QPGKVATFTI 800 NIKAKLDFSC 810 QENLLQDLSD 820 DGISVSGFPL 830 SSPFRQVVRP 840 RVESRPTNPS 850 EGSKTGDLGH 860 VKTLEAVLNF 870 KYSGGPGHVE 880 GYYRNLSLGL 890 HVEVEPSVFF 900 TRVSTLPATS 910 TRQCHLLLDV 920 FNSTEHELTV 930 CARNNSELVL 940 HASECQRMAI 950 QVDKFNFESV 960 PESPGEKGHF 970 ANLKQLEEER 980 QEARGLEISS 990 KLDIRWRIPS 1000 LKRSGEASVE 1010 GLLNQLILEH 1020 LQLAPLQWDV 1030 LVDGQPCDCE 1040 VAAACQVGDP 1050 VRLEVRLTNR 1060 SPRSVGPFAL 1070 TVVPFQDHQN 1080 GVHNYDLHDV 1090 ISFVGSSTFY 1100 LDTVQPSGQS 1110 TCLGALLFLY 1120 TGDFFLNIRF 1130 HEDCKSKELP 1140 PSWVCLPSVH VRALGAQA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005802	trans-Golgi network
Cellular Component	GO:0030008	TRAPP complex
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:0043123	positive regulation of canonical NF-kappaB signal transduction
Biological Process	GO:0006901	vesicle coating
Biological Process	GO:0099022	vesicle tethering

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.