Overview
| Uniprot ID | Q3U0V1 |
|---|
| Protein Name | Far upstream element-binding protein 2 |
|---|
| Gene Name | Khsrp |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 72 |
GGGPGIRKDAFADAV |
Function
Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity)
Protein Sequence
10
MSDYNTGGPP
20
PGPPPPAGGG
30
GGAAGAGGGP
40
PPGPPGAGDR
50
GGGGPGGGGP
60
GGGGASGGPS
70
QPPGGGGPGI
80
RKDAFADAVQ
90
RARQIAAKIG
100
GDAATTVNNN
110
TPDFGFGGQK
120
RQLEDGDQPD
130
SKKLASQGDS
140
IGSQLGPIHP
150
PPRTSMTEEY
160
RVPDGMVGLI
170
IGRGGEQINK
180
IQQDSGCKVQ
190
ISPDSGGLPE
200
RSVSLTGAPE
210
SVQKAKMMLD
220
DIVSRGRGGP
230
PGQFHDNANG
240
GQNGTVQEIM
250
IPAGKAGLVI
260
GKGGETIKQL
270
QERAGVKMIL
280
IQDGSQNTNV
290
DKPLRIIGDP
300
YKVQQACEMV
310
MDILRERDQG
320
GFGDRNEYGS
330
RVGGGIDVPV
340
PRHSVGVVIG
350
RSGEMIKKIQ
360
NDAGVRIQFK
370
QDDGTGPEKI
380
AHIMGPPDRC
390
EHAARIINDL
400
LQSLRSGPPG
410
PPGAPGMPPG
420
GRGRGRGQGN
430
WGPPGGEMTF
440
SIPTHKCGLV
450
IGRGGENVKA
460
INQQTGAFVE
470
ISRQLPPNGD
480
PNFKLFVIRG
490
SPQQIDHAKQ
500
LIEEKIEGPL
510
CPVGPGPGGP
520
GPAGPMGPFN
530
PGPFNQGPPG
540
APPHAGGPPP
550
HQYPPQGWGN
560
TYPQWQPPAP
570
HDPNKAAAAA
580
TDPNAAWAAY
590
YSHYYQQPPG
600
PVPGPAPAPA
610
APPAQGEPPQ
620
PPPTGQSDYT
630
KAWEEYYKKI
640
GQQPQQPGAP
650
PQQDYTKAWE
660
EYYKKQAQVA
670
TGGGPGAPPG
680
SQPDYSAAWA
690
EYYRQQAAYY
700
GQTPGPGGPQ
710
PPPTQQGQQQ
720
ASGNCHPPPP
730
PFSFQPPATV
740
HPALVGSAGN
PFPCGVCP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0035925 |
mRNA 3'-UTR AU-rich region binding |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0044183 |
protein folding chaperone |
| Biological Process |
GO:0061158 |
3'-UTR-mediated mRNA destabilization |
| Biological Process |
GO:0071345 |
cellular response to cytokine stimulus |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0010586 |
miRNA metabolic process |
| Biological Process |
GO:0006402 |
mRNA catabolic process |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0010989 |
negative regulation of low-density lipoprotein particle clearance |
| Biological Process |
GO:0045019 |
negative regulation of nitric oxide biosynthetic process |
| Biological Process |
GO:0061014 |
positive regulation of mRNA catabolic process |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:2000628 |
regulation of miRNA metabolic process |
| Biological Process |
GO:0043488 |
regulation of mRNA stability |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.