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Overview

Uniprot IDQ3UIU2
Protein NameNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Gene NameNdufb6
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
24 ELRRRWLKDQELSPR
63 VWKNMVFKAYRSSLF

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Protein Sequence

10 MSGYTPDEKL 20 RLQQLRELRR 30 RWLKDQELSP 40 REPVLPPRRM 50 WPLERFWDNF 60 LRDGAVWKNM 70 VFKAYRSSLF 80 AVSHVLIPMW 90 FVHYYVKYHM 100 ATKPYTIVSS 110 KPRIFPGDTI 120 LETGEVIPPM RDFPDQHH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0045271 respiratory chain complex I
Biological Process GO:0009060 aerobic respiration
Biological Process GO:0042775 mitochondrial ATP synthesis coupled electron transport
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.