Search Results
Overview
| Uniprot ID | Q3ULD5 |
|---|---|
| Protein Name | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
| Gene Name | Mccc2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 495 | DQKAREGKQFSSAEE |
| 506 | SAEEAALKEPIIKRF |
Function
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism
Protein Sequence
10
MWGALRSALR
20
PCCRAAVPPQ
30
RAYHGDSVAR
40
LGTQPDSASS
50
TYQENYEQMK
60
ALVSQLHERA
70
QYVRLGGSEK
80
ARARHTSRGK
90
LLPRDRIDNL
100
IDPGSPFLEF
110
SQFAGYQLYG
120
DEEVPAGGII
130
TGIGRVSGVE
140
CMIVANDATV
150
KGGTYYPVTV
160
KKHVRAQEIA
170
LQNRLPCIYL
180
VDSGGANLPR
190
QADTFPDRDH
200
FGRIFYNQAI
210
MSSKNITQIA
220
VVMGSCTAGG
230
AYVPAMADEN
240
IIVQKQGTIF
250
LAGPPLVKAA
260
TGEEVSAEDL
270
GGADLHCRKS
280
GVTDHYALDD
290
HHALHLTRKV
300
VRSLNYQKKM
310
DVTIEPSEEP
320
LFPADELYGI
330
VGANLKRSFD
340
VREVIARIVD
350
GSRFNEFKAL
360
YGDTLVTGFA
370
RIFGYPVGII
380
GNNGVLFSES
390
AKKGAHFVQL
400
CCQRNIPLLF
410
LQNITGFMVG
420
RDYEAEGIAK
430
DGAKMVAAVA
440
CAKVPKITVI
450
IGGSYGAGNY
460
GMCGRAYSPR
470
FLYMWPNARI
480
SVMGGEQAAT
490
VLATVARDQK
500
AREGKQFSSA
510
EEAALKEPII
520
KRFEEEGNPY
530
YSSARLWDDG
540
IIDPVDTRLV
550
LGLSLSAALN
560
APIQRTDFGI
FRM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1905202 | methylcrotonoyl-CoA carboxylase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004485 | methylcrotonoyl-CoA carboxylase activity |
| Biological Process | GO:0015936 | coenzyme A metabolic process |
| Biological Process | GO:0006552 | L-leucine catabolic process |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.