Overview
| Uniprot ID | Q3UMU9 |
|---|
| Protein Name | Hepatoma-derived growth factor-related protein 2 |
|---|
| Gene Name | Hdgfl2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 411 |
EGKKLAKKSQLPGSE |
Function
Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin (PubMed:22212508)
Protein Sequence
10
MPHAFKPGDL
20
VFAKMKGYPH
30
WPARIDDIAD
40
GAVKPPPNKY
50
PIFFFGTHET
60
AFLGPKDLFP
70
YDKCKDKYGK
80
PNKRKGFNEG
90
LWEIQNNPHA
100
SYSAPPPVSS
110
SDSEAPEADL
120
GCGSDVDKDK
130
ESRRVMTVTA
140
VTTTATSDRM
150
ESDSDSDKSS
160
DHSGLKRKTP
170
VLKVSVSKRA
180
RRASSDLDQA
190
SVSPSEEDSE
200
SPSESEKTSD
210
QDFTPEKKTA
220
ARPPRRGPLG
230
GRKKKKVPSA
240
SDSDSKADSD
250
GAKEEPVVTA
260
QPSPSSSSSS
270
SSSSSSDSDV
280
SVKKPPRGRK
290
PAEKPPPKPR
300
GRRPKPERPP
310
STSSSDSDSD
320
SGEVDRISEW
330
KRRDEERRRE
340
LEARRRREQE
350
EELRRLREQE
360
REEKERRKER
370
AERGGSSGEE
380
LEDEEPVKKR
390
SRKARGRGTP
400
SSSDSEPEGE
410
LGKEGKKLAK
420
KSQLPGSESA
430
RKPGQKEKRG
440
RPDEKPRARP
450
VKVERTRKRS
460
EGLSLERKGE
470
KKKEPSVEER
480
LQKLHSEIKF
490
ALKVDNPDVR
500
KCLSALEELG
510
TLQVTSQILQ
520
KNTDVVATLK
530
KIRRYKANKD
540
VMAKAAEVYT
550
RLKSRVLGPK
560
VEALQKVNKA
570
GAEKERADNE
580
KLEEQPGEQA
590
PRELAEDEPS
600
TDRSAPVNGE
610
ATSQKGENME
620
DRAQEDGQDS
630
EDGPRGGSSE
640
ELHDSPRDNS
650
DPAKPGNERQ
660
DHERTRLASE
SANDDNEDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0061628 |
histone H3K27me3 reader activity |
| Molecular Function |
GO:0062072 |
histone H3K9me2/3 reader activity |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006310 |
DNA recombination |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0140861 |
DNA repair-dependent chromatin remodeling |
| Biological Process |
GO:0042692 |
muscle cell differentiation |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0030307 |
positive regulation of cell growth |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0043403 |
skeletal muscle tissue regeneration |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.