Search Results
Overview
| Uniprot ID | Q3UQ84 |
|---|---|
| Protein Name | Threonine--tRNA ligase, mitochondrial |
| Gene Name | Tars2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 61 | KLASMTQKKARAIKI |
| 67 | QKKARAIKISLPEGQ |
Function
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain
Protein Sequence
10
MGLCLRWRRL
20
GFPLPEFRRC
30
ELHTVREASA
40
PTPPHWLAER
50
FGLFEELWTA
60
HVKKLASMTQ
70
KKARAIKISL
80
PEGQKVDAVA
90
WNTTPYQLAH
100
QISVTLADTA
110
VAAEVNGELY
120
DLDRPLETDC
130
HLRFLTFDSP
140
EGKAVFWHSS
150
AHVLGAAAEQ
160
QLGAVLCRGP
170
STESGFYHDF
180
FLGKERTVRS
190
AELPILERIC
200
QELIAAAQPF
210
RRLEASRDQL
220
RQLFKDNHFK
230
LHLIEEKVTG
240
PTATVYGCGM
250
SVDLCRGPHL
260
RHTGQIGALK
270
LLTNSSALWR
280
SLGAPETLQR
290
VSGISFPKVE
300
LLRNWEARRE
310
AAELRDHRRI
320
GKEQELFFFH
330
ELSPGSCFFL
340
PRGTRVYNAL
350
VAFIRAEYAR
360
RGFSEVKTPT
370
LFSTKLWEQS
380
GHWEHYRADM
390
FSLKPPGTDG
400
VDNSQSGHPA
410
RCPKDTLALK
420
PMNCPAHCLM
430
FAHRPRSWRE
440
LPVRLADFGA
450
LHRAEASGSL
460
GGLTRLWRFQ
470
QDDAHIFCAP
480
HQLEAEIQGC
490
LDFLRCVYSV
500
LGFSFHLALS
510
TRPPGFLGEP
520
RLWDQAEQVL
530
QQALEKFGEP
540
WDLNPGDGAF
550
YGPKIDVHLH
560
DALGRPHQCG
570
TIQLDFQLPL
580
RFDLQYKGPA
590
GTPECPVLIH
600
RAVLGSVERL
610
LGVLAESCGG
620
KWPLWLSPLQ
630
VVVIPVRTEQ
640
EEYARQVQQC
650
LQAAGLVSDL
660
DADSGLTLSR
670
RVRRAQLAHY
680
NFQFVVGQRE
690
QSQRTVNVRT
700
RDNRQLGERD
710
LAESVQRLLE
720
LQNARVPNAE
EVF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0002161 | aminoacyl-tRNA deacylase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004829 | threonine-tRNA ligase activity |
| Biological Process | GO:0006435 | threonyl-tRNA aminoacylation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.