Search Results

Overview

Uniprot IDQ3URE1
Protein NameMalonate--CoA ligase ACSF3, mitochondrial
Gene NameAcsf3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
411 EGNERGTKVTPGFEE
476 RTSVDIIKTGGYKVS
481 IIKTGGYKVSALEIE
561 IPRNQMGKVNKKELL

Function

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates

Protein Sequence

10 MPPHLALPFR 20 RLFWSLASSQ 30 LIPRRHRGHS 40 LLPTTPEAHT 50 DGSVPVFIRA 60 LAFGDRIALI 70 DKYGHHTYRE 80 LYDRSLCLAQ 90 EICRLQGCKV 100 GDLQEERVSF 110 LCSNDVSYVV 120 AQWASWMSGG 130 VAVPLYWKHP 140 EAQLEYFIQD 150 SRSSLVVVGQ 160 EYLERLSPLA 170 QRLGVPLLPL 180 TPAVYHGATE 190 KPTEQPVEES 200 GWRDRGAMIF 210 YTSGTTGRPK 220 GALSTHRNLA 230 AVVTGLVHSW 240 AWTKNDVILH 250 VLPLHHVHGV 260 VNKLLCPLWV 270 GATCVMLPEF 280 SAQQVWEKFL 290 SSEAPQITVF 300 MAVPTVYSKL 310 LDYYDKHFTQ 320 PHVQDFVRAV 330 CKERIRLMVS 340 GSAALPVPLL 350 EKWRSATGHT 360 LLERYGMTEI 370 GMALSNPLTE 380 ARVPGSVGTP 390 LPGVEVRIIS 400 ENPQKGSPYI 410 IHAEGNERGT 420 KVTPGFEEKE 430 GELLVRGPSV 440 FREYWDKPEE 450 TKSAFTSDGW 460 FRTGDTAVFK 470 DARYWIRGRT 480 SVDIIKTGGY 490 KVSALEIERH 500 LLAHPSITDV 510 AVIGVPDMTW 520 GQRVTAVVAL 530 QEGHSLSHGD 540 LKEWARGVLA 550 PYAVPSELLL 560 VEEIPRNQMG 570 KVNKKELLKQ 580 LYPSGQRSQP GQG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016405 CoA-ligase activity
Molecular Function GO:0090409 malonyl-CoA synthetase activity
Molecular Function GO:0031957 very long-chain fatty acid-CoA ligase activity
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0090410 malonate catabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.