Search Results
Overview
| Uniprot ID | Q3UUI3 |
|---|---|
| Protein Name | Acyl-coenzyme A thioesterase THEM4 |
| Gene Name | Them4 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 98 | KKEEQMSKAQQFTRS |
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (PubMed:19421406)
Protein Sequence
10
MLRNCAMRLR
20
TLGATPARRP
30
GAARRLFSSE
40
KVIRKDYALP
50
NPSWTKDLRL
60
LFDQFMKKCE
70
DGSWKRMPSH
80
RQNPTRAIQE
90
FQTLFVDSKF
100
KKEEQMSKAQ
110
QFTRSFEEGL
120
GFEYAMFYNK
130
VEKRTVSLFQ
140
GGLHLQGVPG
150
FVHGGAIATI
160
IDVTTGTCAI
170
SEGVAMTANL
180
NITYKKPIPL
190
LSVVVVNSQL
200
QKIEGRKLFV
210
SCTIQSIDEK
220
TLYTEATALF
230
IKLDPEKPLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.