Search Results
Overview
| Uniprot ID | Q3UV70 |
|---|---|
| Protein Name | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial |
| Gene Name | Pdp1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 326 | ERELERLKLEHPKNE |
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA
Protein Sequence
10
MPAPTQLFFP
20
LVRNCELSRI
30
YGTACYCHHK
40
HLCCSPPYIP
50
QNRLRYTPHP
60
AYATFCRPRE
70
NWWQYTQGRR
80
YASTPQKFYL
90
TPPQVNSILK
100
ANEYSFKVPE
110
FDGKNVSSIL
120
GFDSNQLPAN
130
APIEDRRSAA
140
TCLQTRGMLL
150
GVFDGHAGCA
160
CSQAVSERLF
170
YYIAVSLLPH
180
ETLLEIENAV
190
ESGRALLPIL
200
QWHKHPNDYF
210
SKEASKLYFN
220
SLRTYWQELI
230
DLNTGESADI
240
DVKEALINAF
250
KRLDNDISLE
260
AQVGDPNSFL
270
NYLVLRVAFS
280
GATACVAHVD
290
GVDLHVANTG
300
DSRAMLGVQE
310
EDGSWSAVTL
320
SNDHNAQNER
330
ELERLKLEHP
340
KNEAKSVVKQ
350
DRLLGLLMPF
360
RAFGDVKFKW
370
SIDLQKRVIE
380
SGPDQLNDNE
390
YTKFIPPNYH
400
TPPYLTAEPE
410
VTYHRLRPQD
420
KFLVLATDGL
430
WETMHRQDVV
440
RIVGEYLTGM
450
HHQQPIAVGG
460
YKVTLGQMHG
470
LLTERRAKMS
480
SVFEDQNAAT
490
HLIRHAVGNN
500
EFGAVDHERL
510
SKMLSLPEEL
520
ARMYRDDITI
530
IVVQFNSHVV
GAYQNQEQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004741 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0035970 | peptidyl-threonine dephosphorylation |
| Biological Process | GO:0140176 | positive regulation of pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:0010510 | regulation of pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.