Search Results
Overview
| Uniprot ID | Q3V384 |
|---|---|
| Protein Name | AFG1-like ATPase |
| Gene Name | Afg1l |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 328 | LTSPRILKVQGRELR |
Function
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress
Protein Sequence
10
MAASWSPLVT
20
LRSAARSRLT
30
GRGVGCGARV
40
VAIPPPAPGP
50
GKPLWKAYTV
60
QTSEGVRPTA
70
ASEARLKALA
80
VCHGPLDHYD
90
FLIKSQELRE
100
DEHQRRVVQC
110
LQKLQEDLKG
120
YSIEEGGLFS
130
KLFSRNKPPK
140
GLYVYGDVGT
150
GKTMVMDMFY
160
AYVETKRKKR
170
VHFHGFMLDV
180
HRRIHHLKQS
190
LPKRKAGFMA
200
KSYDPIAPIA
210
EEISQETSLL
220
CFDEFQVTDI
230
ADAMILKQLF
240
ENLFKNGVVV
250
VATSNRPPED
260
LYKNGLQRAN
270
FVPFIAVLKE
280
YCDTLQLDSG
290
VDYRKRELAP
300
AGKLYYLTSE
310
ADVEAVVDKL
320
FDELAQKQND
330
LTSPRILKVQ
340
GRELRLNKAC
350
GSVADCTFEE
360
LCERPLGASD
370
YLELSKNFDT
380
VIIRNIPQFS
390
LAKRTQARRF
400
ITLIDNFYDF
410
KVRIICSASA
420
PISSLFLHQH
430
QDSESDQSRI
440
LMDDLGLSQD
450
SAGLSMFTGE
460
EEIFAFQRTI
470
SRLTEMQTEQ
480
YWIEGDRSRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Biological Process | GO:0035694 | mitochondrial protein catabolic process |
| Biological Process | GO:0141164 | mitochondrial protein quality control |
| Biological Process | GO:0007005 | mitochondrion organization |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.