Search Results

Overview

Uniprot IDQ3YEC7
Protein NameRab-like protein 6
Gene NameRABL6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
7 *MFSALKKLVGSDQA

Function

Small GTPase involved in the regulation of cell growth and survival (PubMed:19433581). Promotes cellular proliferation (PubMed:16582619, PubMed:19433581). May reduce growth inhibitory activity of CDKN2A (PubMed:16582619)

Protein Sequence

10 MFSALKKLVG 20 SDQAPGRDKN 30 IPAGLQSMNQ 40 ALQRRFAKGV 50 QYNMKIVIRG 60 DRNTGKTALW 70 HRLQGRPFVE 80 EYIPTQEIQV 90 TSIHWSYKTT 100 DDIVKVEVWD 110 VVDKGKCKKR 120 GDGLKMENDP 130 QEAESEMALD 140 AEFLDVYKNC 150 NGVVMMFDIT 160 KQWTFNYILR 170 ELPKVPTHVP 180 VCVLGNYRDM 190 GEHRVILPDD 200 VRDFIDNLDR 210 PPGSSYFRYA 220 ESSMKNSFGL 230 KYLHKFFNIP 240 FLQLQRETLL 250 RQLETNQLDM 260 DATLEELSVQ 270 QETEDQNYGI 280 FLEMMEARSR 290 GHASPLAANG 300 QSPSPGSQSP 310 VVPAGAVSTG 320 SSSPGTPQPA 330 PQLPLNAAPP 340 SSVPPVPPSE 350 ALPPPACPSA 360 PAPRRSIISR 370 LFGTSPATEA 380 APPPPEPVPA 390 AEGPATVQSV 400 EDFVPDDRLD 410 RSFLEDTTPA 420 RDEKKVGAKA 430 AQQDSDSDGE 440 ALGGNPMVAG 450 FQDDVDLEDQ 460 PRGSPPLPAG 470 PVPSQDITLS 480 SEEEAEVAAP 490 TKGPAPAPQQ 500 CSEPETKWSS 510 IPASKPRRGT 520 APTRTAAPPW 530 PGGVSVRTGP 540 EKRSSTRPPA 550 EMEPGKGEQA 560 SSSESDPEGP 570 IAAQMLSFVM 580 DDPDFESEGS 590 DTQRRADDFP 600 VRDDPSDVTD 610 EDEGPAEPPP 620 PPKLPLPAFR 630 LKNDSDLFGL 640 GLEEAGPKES 650 SEEGKEGKTP 660 SKEKKKKKKK 670 GKEEEEKAAK 680 KKSKHKKSKD 690 KEEGKEERRR 700 RQQRPPRSRE 710 RTAADELEAF 720 LGGGAPGGRH PGGGDYEEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0046872 metal ion binding

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.