Search Results
Overview
| Uniprot ID | Q3ZAV8 |
|---|---|
| Protein Name | Enhancer of mRNA-decapping protein 4 |
| Gene Name | Edc4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 913 | PTPRLPAKDWKTKGS |
Function
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)
Protein Sequence
10
MASCASIDIE
20
DATQHLRDIL
30
KLDRPAGGSN
40
VESQRPSSAY
50
NGDLNGLLVP
60
DPLSSGDGNS
70
TSKPGIRTMP
80
PINLQEKQVI
90
CLSGDDSSTC
100
IGILAKEVEI
110
VASSDSSISS
120
KARGSNKVKI
130
QPVAKYDWEQ
140
KYYYGNLIAV
150
SNSFLAYAIR
160
AANNGSAMVR
170
VISVSTSERT
180
LLKGFTGSVA
190
DLAFAHLNSP
200
QLACLDEAGD
210
LFVWRLALVK
220
GKIQEEILVH
230
IRQPEGTPLN
240
HFRRIIWCPF
250
IPEESEDCCE
260
ESSPTVALLH
270
EDRAEVWDLD
280
MLRSSHSTWP
290
VDVSQIKQGF
300
IVVKGHSTCL
310
SEGALSPDGT
320
VLATASHDGF
330
VKFWQIYIEG
340
QDEPRCLHEW
350
KPHDGRPLSC
360
LLFCDNHKKQ
370
DPEVPFWRFL
380
ITGADQNREL
390
KMWCTVSWTC
400
LQTIRFSPDI
410
FSSVSVPPSL
420
KVCLDLSAEY
430
LILSDVQRKV
440
LYVMELLQNQ
450
DEGRACFSSI
460
SEFLLTHPVL
470
SFGIQVVSRC
480
RLRHTEVLPA
490
EEESDSLGTE
500
SSHGAGTLES
510
AAGVLIKLFC
520
VHTKALQDVQ
530
IRFQPQLNPD
540
VVAPLSTHTA
550
HEDFTFGESR
560
PELGSEGLAS
570
APHGSQPDLR
580
RIVELPAPAD
590
FLSLSSETKP
600
KLMTPDAFMT
610
PTASLQQISA
620
SPSSSSSSSS
630
SSSSSSSSSS
640
SSSLTAVSAV
650
SSSSAMDPSL
660
PSRPPEELTL
670
SPKLQLDGSL
680
TISSSSSLQA
690
SPRSLLPGLL
700
PGPADKLIPK
710
GPGQVSSGTS
720
ALSLDLQEVE
730
PLGLPQASPS
740
RTRSPDVISS
750
ASTALSQDIP
760
EIASEALSRG
770
FGSSVPEGLI
780
EPDSMASAAS
790
ALHLLSPRPR
800
QGPELSSQLG
810
LDGGPGDGDR
820
HSTPSLLEAA
830
LTQEVATSDS
840
QVWPTAPDIT
850
RETCSTLTES
860
PRNGLQEKHK
870
SLAFHRPPYH
880
LLQQHDSQDT
890
SAEQSDHDDE
900
VASLASASGG
910
FGSKIPTPRL
920
PAKDWKTKGS
930
PRTSPKLKRK
940
SKKDDGDSAV
950
GSRLTEHQVV
960
EPPEDWPALI
970
WQQQRELAEL
980
WHNQEELLQR
990
LCAQLEGLQS
1000
TVTDHVERAL
1010
ETRHEQEQRR
1020
LERALAEGQQ
1030
RGGQLQEQLT
1040
QQLSQALSSA
1050
VAGRLERSIR
1060
DEIKKTVPPC
1070
VSRSLEPVAG
1080
QLSNSVATKL
1090
TAVEGSMKEN
1100
ISKLLKSKNL
1110
TDAIARAAAD
1120
TLQGPMQAAY
1130
REAFQSVVLP
1140
AFEKSCQAMF
1150
QQINDSFRLG
1160
TQEYLQQLDS
1170
HMKSRKAREQ
1180
EAREPVLAQL
1190
RGLVSTLQNA
1200
TEQMAATVSS
1210
SVRAEVQHQL
1220
HVAVGSLQES
1230
ILAQVQRIVK
1240
GEVSVALKEQ
1250
QATVTSSIMQ
1260
AMRSAAGTPV
1270
PSAHLDCQAQ
1280
QAHILQLLQQ
1290
GHLNQAFQQA
1300
LTAADLNLVL
1310
YVCETVDPAQ
1320
VFGQPPCPLS
1330
QPVLLSLIQQ
1340
LASDLGTRSD
1350
LKLSYLEEAV
1360
MHLDHSDPIT
1370
RDHMGSVMAQ
1380
VRQKLFQFLQ
1390
ADPHNSLGKA
1400
ARRLSLMLHG
LVTPSLP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000932 | P-body |
| Biological Process | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.