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Overview

Uniprot IDQ3ZAV8
Protein NameEnhancer of mRNA-decapping protein 4
Gene NameEdc4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
913 PTPRLPAKDWKTKGS

Function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)

Protein Sequence

10 MASCASIDIE 20 DATQHLRDIL 30 KLDRPAGGSN 40 VESQRPSSAY 50 NGDLNGLLVP 60 DPLSSGDGNS 70 TSKPGIRTMP 80 PINLQEKQVI 90 CLSGDDSSTC 100 IGILAKEVEI 110 VASSDSSISS 120 KARGSNKVKI 130 QPVAKYDWEQ 140 KYYYGNLIAV 150 SNSFLAYAIR 160 AANNGSAMVR 170 VISVSTSERT 180 LLKGFTGSVA 190 DLAFAHLNSP 200 QLACLDEAGD 210 LFVWRLALVK 220 GKIQEEILVH 230 IRQPEGTPLN 240 HFRRIIWCPF 250 IPEESEDCCE 260 ESSPTVALLH 270 EDRAEVWDLD 280 MLRSSHSTWP 290 VDVSQIKQGF 300 IVVKGHSTCL 310 SEGALSPDGT 320 VLATASHDGF 330 VKFWQIYIEG 340 QDEPRCLHEW 350 KPHDGRPLSC 360 LLFCDNHKKQ 370 DPEVPFWRFL 380 ITGADQNREL 390 KMWCTVSWTC 400 LQTIRFSPDI 410 FSSVSVPPSL 420 KVCLDLSAEY 430 LILSDVQRKV 440 LYVMELLQNQ 450 DEGRACFSSI 460 SEFLLTHPVL 470 SFGIQVVSRC 480 RLRHTEVLPA 490 EEESDSLGTE 500 SSHGAGTLES 510 AAGVLIKLFC 520 VHTKALQDVQ 530 IRFQPQLNPD 540 VVAPLSTHTA 550 HEDFTFGESR 560 PELGSEGLAS 570 APHGSQPDLR 580 RIVELPAPAD 590 FLSLSSETKP 600 KLMTPDAFMT 610 PTASLQQISA 620 SPSSSSSSSS 630 SSSSSSSSSS 640 SSSLTAVSAV 650 SSSSAMDPSL 660 PSRPPEELTL 670 SPKLQLDGSL 680 TISSSSSLQA 690 SPRSLLPGLL 700 PGPADKLIPK 710 GPGQVSSGTS 720 ALSLDLQEVE 730 PLGLPQASPS 740 RTRSPDVISS 750 ASTALSQDIP 760 EIASEALSRG 770 FGSSVPEGLI 780 EPDSMASAAS 790 ALHLLSPRPR 800 QGPELSSQLG 810 LDGGPGDGDR 820 HSTPSLLEAA 830 LTQEVATSDS 840 QVWPTAPDIT 850 RETCSTLTES 860 PRNGLQEKHK 870 SLAFHRPPYH 880 LLQQHDSQDT 890 SAEQSDHDDE 900 VASLASASGG 910 FGSKIPTPRL 920 PAKDWKTKGS 930 PRTSPKLKRK 940 SKKDDGDSAV 950 GSRLTEHQVV 960 EPPEDWPALI 970 WQQQRELAEL 980 WHNQEELLQR 990 LCAQLEGLQS 1000 TVTDHVERAL 1010 ETRHEQEQRR 1020 LERALAEGQQ 1030 RGGQLQEQLT 1040 QQLSQALSSA 1050 VAGRLERSIR 1060 DEIKKTVPPC 1070 VSRSLEPVAG 1080 QLSNSVATKL 1090 TAVEGSMKEN 1100 ISKLLKSKNL 1110 TDAIARAAAD 1120 TLQGPMQAAY 1130 REAFQSVVLP 1140 AFEKSCQAMF 1150 QQINDSFRLG 1160 TQEYLQQLDS 1170 HMKSRKAREQ 1180 EAREPVLAQL 1190 RGLVSTLQNA 1200 TEQMAATVSS 1210 SVRAEVQHQL 1220 HVAVGSLQES 1230 ILAQVQRIVK 1240 GEVSVALKEQ 1250 QATVTSSIMQ 1260 AMRSAAGTPV 1270 PSAHLDCQAQ 1280 QAHILQLLQQ 1290 GHLNQAFQQA 1300 LTAADLNLVL 1310 YVCETVDPAQ 1320 VFGQPPCPLS 1330 QPVLLSLIQQ 1340 LASDLGTRSD 1350 LKLSYLEEAV 1360 MHLDHSDPIT 1370 RDHMGSVMAQ 1380 VRQKLFQFLQ 1390 ADPHNSLGKA 1400 ARRLSLMLHG LVTPSLP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Biological Process GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.