Search Results
Overview
| Uniprot ID | Q3ZCQ8 |
|---|---|
| Protein Name | Mitochondrial import inner membrane translocase subunit TIM50 |
| Gene Name | TIMM50 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | IGSRGSTKAQGPQQQ |
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:30190335, PubMed:38828998). Has some phosphatase activity in vitro; however such activity may not be relevant in vivo
Protein Sequence
10
MAASAAVFSR
20
LRSGLRLGSR
30
GLCTRLATPP
40
RRAPDQAAEI
50
GSRGSTKAQG
60
PQQQPGSEGP
70
SYAKKVALWL
80
AGLLGAGGTV
90
SVVYIFGNNP
100
VDENGAKIPD
110
EFDNDPILVQ
120
QLRRTYKYFK
130
DYRQMIIEPT
140
SPCLLPDPLQ
150
EPYYQPPYTL
160
VLELTGVLLH
170
PEWSLATGWR
180
FKKRPGIETL
190
FQQLAPLYEI
200
VIFTSETGMT
210
AFPLIDSVDP
220
HGFISYRLFR
230
DATRYMDGHH
240
VKDISCLNRD
250
PARVVVVDCK
260
KEAFRLQPYN
270
GVALRPWDGN
280
SDDRVLLDLS
290
AFLKTIALNG
300
VEDVRTVLEH
310
YALEDDPLAA
320
FKQRQSRLEQ
330
EEQQRLAELS
340
KSNKQNLFLG
350
SLTSRLWPRS
KQP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Molecular Function | GO:0140608 | cysteine-type endopeptidase activator activity |
| Molecular Function | GO:0005134 | interleukin-2 receptor binding |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007006 | mitochondrial membrane organization |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.