Search Results

Overview

Uniprot ID	Q42777
Protein Name	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene Name	MCCA
Organism	Glycine max

Kla Sites from experimental identification

Position	Flanking peptide
679	VKVLVENKTRVEEGQ

Function

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Protein Sequence

10 MASLALLRRT 20 TLSHSHVRAR 30 AFSEGKSSNR 40 HRIEKILVAN 50 RGEIACRITR 60 TARRLGIQTV 70 AVYSDADRDS 80 LHVATADEAI 90 RIGPPPARLS 100 YLNGASIVDA 110 AIRSGAQAIH 120 PGYGFLSESA 130 DFAKLCEESG 140 LTFIGPPASA 150 IRDMGDKSAS 160 KRIMGAAGVP 170 LVPGYHGYDQ 180 DIEKMKLEAD 190 RIGYPVLIKP 200 THGGGGKGMR 210 IVHTPDEFVE 220 SFLAAQREAA 230 ASFGVNTILL 240 EKYITRPRHI 250 EVQIFGDKHG 260 NVLHLYERDC 270 SVQRRHQKII 280 EEAPAPNISA 290 DFRAQLGVAA 300 VSAAKAVNYY 310 NAGTVEFIVD 320 TVSDEFYFME 330 MNTRLQVEHP 340 VTEMIVGQDL 350 VEWQILVANG 360 EALPLSQSQV 370 PLSGHAFEAR 380 IYAENVQKGF 390 LPATGVLHHY 400 HVPVSSAVRV 410 ETGVKEGDKV 420 SMHYDPMIAK 430 LVVWGENRAA 440 ALVKLKDSLS 450 KFQVAGLPTN 460 VNFLQKLANH 470 RAFAIGNVET 480 HFIDNYKEDL 490 FVDANNSVSV 500 KEAYEAARLN 510 ASLVAACLIE 520 KEHFILARNP 530 PGGSSLLPIW 540 YSSPPFRIHH 550 QAKRRMELEW 560 DNEYGSGSSK 570 IMKLTITYQP 580 DGRYLIETEQ 590 NGSPVLEVKS 600 TYVKDNYFRV 610 EAAGVINDVN 620 VAVYSKDQIR 630 HIHIWQGSCH 640 HYFREKLGLE 650 LSEDEESQHK 660 PKVETSANPQ 670 GTVVAPMAGL 680 VVKVLVENKT 690 RVEEGQPVLV 700 LEAMKMEHVV 710 KAPSSGYVHG 720 LQLMVGEQVS 730 DGSVLFSVKD Q

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004485	methylcrotonoyl-CoA carboxylase activity
Biological Process	GO:0006552	L-leucine catabolic process

Reference

[1] Xu C, Li J, Dong C, Zhang Y, Li H et al.. Lactylome Profiling Reveals the Potential Role of Lysine Lactylation in Regulating Soybean Seed Quality.. J Agric Food Chem 73(23):14666-14676. 2025 Jun 11. PMID: 40440508.