Search Results
Overview
| Uniprot ID | Q45FY6 |
|---|---|
| Protein Name | Hypoxanthine-guanine phosphoribosyltransferase |
| Gene Name | HPRT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | TVDFIRLKSYCNDQS |
| 159 | QHNPKMVKVASLLVK |
| 213 | CVISETGKAKYKA** |
Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)
Protein Sequence
10
MATRSPSVVI
20
SDDEPGYDLD
30
LFCIPNHYAE
40
DLEKVFIPHG
50
LIMDRTERLA
60
RDVMKEMGGH
70
HIVALCVLKG
80
GYKFFADLLD
90
YIKALNRNSD
100
RSIPMTVDFI
110
RLKSYCNDQS
120
TGDIKVIGGD
130
DLSTLTGKNV
140
LIVEDIIDTG
150
KTMQTLLSLV
160
KQHNPKMVKV
170
ASLLVKRTPR
180
SVGYRPDFVG
190
FEIPDKFVVG
200
YALDYNEYFR
210
DLNHVCVISE
TGKAKYKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0052657 | guanine phosphoribosyltransferase activity |
| Molecular Function | GO:0004422 | hypoxanthine phosphoribosyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0046038 | GMP catabolic process |
| Biological Process | GO:0032263 | GMP salvage |
| Biological Process | GO:0006178 | guanine salvage |
| Biological Process | GO:0046100 | hypoxanthine metabolic process |
| Biological Process | GO:0043103 | hypoxanthine salvage |
| Biological Process | GO:0046040 | IMP metabolic process |
| Biological Process | GO:0032264 | IMP salvage |
| Biological Process | GO:0045964 | positive regulation of dopamine metabolic process |
| Biological Process | GO:0006164 | purine nucleotide biosynthetic process |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.