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Overview

Uniprot IDQ498D1
Protein NameForkhead box protein P1
Gene NameFoxp1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
582 FQKRRPQKISGNPSL

Function

Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity)

Protein Sequence

10 MMQESGSEAK 20 SNGSTIQNGS 30 SGGNHLLECG 40 TLRDTRSNGE 50 APAVDLGAAD 60 LAHVQQQQQQ 70 ALQVARQLLL 80 QQQQQQQQQQ 90 QQQQQQQQQQ 100 QQQQQQQQQQ 110 QQQQQQQQQV 120 SGLKSPKRND 130 KQPALQVPVS 140 VAMMTPQVIT 150 PQQMQQILQQ 160 QVLSPQQLQV 170 LLQQQQALML 180 QQQQLQEFYK 190 KQQEQLQLQL 200 LQQQHAGKQP 210 KEQQQQQVAT 220 QQLAFQQQLL 230 QMQQLQQQHL 240 LSLQRQGLLT 250 IQPGQPALPL 260 QPLAQGMIPT 270 ELQQLWKEVT 280 SAHTAEETTG 290 SNHSSLDLTS 300 TCVSSSAPSK 310 TSLIMNPHAS 320 TNGQLSVHTP 330 KRESLSHEEH 340 PHSHPLYGHG 350 VCKWPGCEAV 360 CDDFPAFLKH 370 LNSEHALDDR 380 STAQCRVQMQ 390 VVQQLELQLA 400 KDKERLQAMM 410 THLHVKSTEP 420 KAAPQPLNLV 430 SSVTLSKSAS 440 EASPQSLPHT 450 PTTPTAPLTP 460 VTQGPSVITT 470 TSMHTVGPIR 480 RRYSDKYNVP 490 ISSADIAQNQ 500 EFYKNAEVRP 510 PFTYASLIRQ 520 AILESPEKQL 530 TLNEIYNWFT 540 RMFAYFRRNA 550 ATWKNAVRHN 560 LSLHKCFVRV 570 ENVKGAVWTV 580 DEVEFQKRRP 590 QKISGNPSLI 600 KNMQSGHAYC 610 TPLNAALQAS 620 MAENSIPLYT 630 TASMGNPTLG 640 SLASAIREEL 650 NGAMEHTNSN 660 ESDSSPGRSP 670 MQAVHPIHVK 680 EEPLDPEEAE 690 GPLSLVTTAN 700 HSPDFDHDRD 710 YEDEPVNEDM E

Gene Ontology

Classification GO ID Description
Biological Process GO:0042116 macrophage activation
Biological Process GO:0042117 monocyte activation
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001046 core promoter sequence-specific DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0050681 nuclear androgen receptor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0055007 cardiac muscle cell differentiation
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042118 endothelial cell activation
Biological Process GO:0030900 forebrain development
Biological Process GO:0007507 heart development
Biological Process GO:0033152 immunoglobulin V(D)J recombination
Biological Process GO:0030324 lung development
Biological Process GO:0061140 lung secretory cell differentiation
Biological Process GO:0008045 motor neuron axon guidance
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0002903 negative regulation of B cell apoptotic process
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1901250 negative regulation of lung goblet cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0036035 osteoclast development
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0050861 positive regulation of B cell receptor signaling pathway
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
Biological Process GO:0002639 positive regulation of immunoglobulin production
Biological Process GO:0032745 positive regulation of interleukin-21 production
Biological Process GO:0002053 positive regulation of mesenchymal cell proliferation
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:1904263 positive regulation of TORC1 signaling
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0002329 pre-B cell differentiation
Biological Process GO:0060765 regulation of androgen receptor signaling pathway
Biological Process GO:0060043 regulation of cardiac muscle cell proliferation
Biological Process GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:1900424 regulation of defense response to bacterium
Biological Process GO:1901509 regulation of endothelial tube morphogenesis
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0032651 regulation of interleukin-1 beta production
Biological Process GO:0032655 regulation of interleukin-12 production
Biological Process GO:1901249 regulation of lung goblet cell differentiation
Biological Process GO:1901256 regulation of macrophage colony-stimulating factor production
Biological Process GO:0045655 regulation of monocyte differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032680 regulation of tumor necrosis factor production
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0033574 response to testosterone
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0048745 smooth muscle tissue development
Biological Process GO:0021756 striatum development
Biological Process GO:0061470 T follicular helper cell differentiation
Biological Process GO:0021517 ventral spinal cord development

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.