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Overview

Uniprot IDQ498U4
Protein NameSAP domain-containing ribonucleoprotein
Gene NameSarnp
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
119 VPVSLESKKAARAAR
135 GISSVPTKGLSSDTK
31 GLETKGIKQDLINRL
88 VVDMASEKKVVKITS
92 ASEKKVVKITSGIPQ

Function

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export

Protein Sequence

10 MATETVELHK 20 LKLAELKQEC 30 LARGLETKGI 40 KQDLINRLQA 50 YLEEHAEEEA 60 NEEDVLGDET 70 EEEEPKPIEL 80 PVKEEEPPEK 90 VVDMASEKKV 100 VKITSGIPQT 110 ERMQKRAERF 120 NVPVSLESKK 130 AARAARFGIS 140 SVPTKGLSSD 150 TKPMVNLDKL 160 KERAQRFGLN 170 VSSISRKSED 180 DEKLKKRKER 190 FGIVTSSAGT 200 GTTEDTEAKK 210 RKRAERFGIA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000346 transcription export complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0016973 poly(A)+ mRNA export from nucleus
Biological Process GO:0006417 regulation of translation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.