Search Results

Overview

Uniprot ID	Q499N5
Protein Name	Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene Name	Acsf2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
182	IVFPKQFKTQQYYNI
199	QVCPELEKAQPGALK
340	SPSFNGKKALEAISR
510	CRIVGRSKDMIIRGG
576	IKAFCKGKISHFKIP

Function

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation

Protein Sequence

10 MAVYLGMLRL 20 GRLCVASLGA 30 RGPRTPLSRP 40 WPNSKLQGVR 50 AFSSGMVDCT 60 NPLPIGGLSY 70 IQGHTDSHLV 80 NKTVGECLDA 90 TAQRFPNREA 100 LVIIHENIRL 110 NFAQLKEEVD 120 RAASGLLSIG 130 LRKGDRLGMW 140 GPNSYAWVLI 150 QLATAQAGII 160 LVSVNPAYQA 170 SELEYVLRKV 180 GCKGIVFPKQ 190 FKTQQYYNIL 200 KQVCPELEKA 210 QPGALKSERL 220 PDLTTVISVD 230 APLPGTLLLD 240 EVVAAGGKEQ 250 NLAQLRYHQG 260 FLSCYDPINI 270 QFTSGTTGNP 280 KGATLSHHNI 290 VNNSNLIGQR 300 LKMPAKTAEE 310 LRMVLPCPLY 320 HCLGSVGGTM 330 VSVVHGATLL 340 LSSPSFNGKK 350 ALEAISREKG 360 TLLYGTPTMF 370 VDILNQPDFS 380 SYDFTTIRGG 390 VIAGSLAPPE 400 LIRAIISKMN 410 MKELVVVYGT 420 TENSPVTFMN 430 FPEDTLEQKA 440 GSVGRIMPHT 450 EAQIVNMETG 460 ELTKLNMPGE 470 LCIRGYCVMQ 480 GYWGEPQKTF 490 ETVGQDRWYR 500 TGDIASMDEQ 510 GFCRIVGRSK 520 DMIIRGGENI 530 YPAELEDFFH 540 KHPQVQEAQV 550 VGVKDDRMGE 560 EICACIRLKS 570 GETTTEEEIK 580 AFCKGKISHF 590 KIPRYIVFVE 600 GYPLTVSGKI 610 QKFKLREQME QHLKL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Biological Process	GO:0006631	fatty acid metabolic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.