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Overview

Uniprot IDQ499N6
Protein NameUBX domain-containing protein 1
Gene NameUbxn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
154 AEERRREKAEELAAR
178 DKAERAQKYGGTVGS

Function

Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity)

Protein Sequence

10 MAELTALESL 20 IEMGFPRGRA 30 EKALALTGNQ 40 GIEAAMDWLM 50 EHEDDPDVDE 60 PLETPLSHIL 70 GREPTPSEQV 80 GPEGSGSAAG 90 ESKPVLTEEE 100 RQEQTKRMLE 110 LVAQKQRERE 120 EREEREALER 130 EKQRRRQGQE 140 LSAARQKLQE 150 DEIRRAAEER 160 RREKAEELAA 170 RQRVREKIER 180 DKAERAQKYG 190 GTVGSRSSPP 200 ATDPGPVPSS 210 PRQEPPTKRE 220 YDQCRIQVRL 230 PDGTSLTQTF 240 RAREQLAAVR 250 LYVELHRGEE 260 PGQDQDPVQL 270 LSGFPRRAFS 280 EADMERPLQE 290 LGLVPSAVLI VAKKCPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0036435 K48-linked polyubiquitin modification-dependent protein binding
Molecular Function GO:0071796 K6-linked polyubiquitin modification-dependent protein binding
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Molecular Function GO:1904855 proteasome regulatory particle binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:1904293 negative regulation of ERAD pathway
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:1903094 negative regulation of protein K48-linked deubiquitination
Biological Process GO:0031397 negative regulation of protein ubiquitination

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.