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Overview

Uniprot ID	Q499R0
Protein Name	Zinc finger protein 518A
Gene Name	Znf518a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
197	YTLLDLTKHFTSKHC

Function

Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes

Protein Sequence

10 MPFEQTQLFC 20 DEKQTILKKI 30 DTRNEIPDTI 40 KSIPIPKISE 50 AGFHYEPKNV 60 NICLPKINIP 70 NEILMKHEVE 80 KYRKLFQSKP 90 QTARKSVSVR 100 TVSCAKGCAQ 110 RCESERAEDE 120 AGKMCAKILN 130 FTCSKCQDRT 140 QYSPNDLQKH 150 FEMWHHGELP 160 SFPCEMCSFS 170 ASDFQIFKQH 180 RKTHRNTFVK 190 CDICNSERSY 200 TLLDLTKHFT 210 SKHCVNGNFQ 220 CEECRFFTQD 230 VGTFVQHIHR 240 HKEVHYKCGK 250 CHHLCFTKGE 260 LQKHLRVHSG 270 TLPFTCHYCS 280 YGAIHKDQLV 290 RHVITLHKEH 300 LYAKEKLERD 310 QYDKRVAKTT 320 TGLKLILKRY 330 KIGPTKTFWK 340 RKTIASGNDE 350 SIGKNAQAFN 360 IVSKTQTKSE 370 DQSQEQLNEE 380 KGGRQHCEDG 390 DKPIESGSEK 400 ATVLSTGQCN 410 KADEGASAPS 420 SVLSAVQGPT 430 VLLVRNNKIT 440 IPANYSAKFM 450 GFKMVDGRQH 460 IVIKLLPANK 470 QILPSPALQP 480 NTEKESTANL 490 PPQAMDNTGF 500 ATGLTAMNDT 510 DFVKAAPLSC 520 SSPELPRKVI 530 SEKETAFISE 540 KNNMLQMVDD 550 SKSVTSLPTP 560 SESVTSVRLT 570 TKVEARDNVD 580 LWENPSTQSH 590 PDLIGTSINS 600 PDKVNLTIRP 610 NAYSCGDMHN 620 YCINYVNSEL 630 PAESSNCFEF 640 SNQGSLPFHN 650 YSKVNNKRRR 660 FSRGAVCENL 670 QRESSNKTVT 680 QQSTSDSDTT 690 SPLRKESSNS 700 DSLLASISPL 710 SGTLKIKTEI 720 EEPCDLEETQ 730 NFNEQSLFTN 740 ENQNLLNMTE 750 EPKWDDIPCA 760 GSPMMPRITS 770 VFSLQSEQAS 780 EFLPPEVNQL 790 LQDTLKPRSD 800 IKEDSNNIPS 810 KNLPLDCDQT 820 LKKSKEEVIK 830 SSKDFQMQDI 840 ISVPSASVGV 850 NVPANDLNLK 860 CNGQEKQALS 870 VLQDVRDPGV 880 TTKIPSIITL 890 LKTQSDAIIT 900 QQLVKDKLRT 910 TTQHSGPVYV 920 QNPLLTSEQK 930 NPVFVQTPKG 940 FIIPLHVANK 950 PGLHVFSGRP 960 VPLVNTQSVP 970 AALLVNKKPG 980 VVLTVNNGKP 990 EGVPTVKTEN 1000 VHSYGTVTKE 1010 PCRTPFLKAE 1020 HNRYCLTPGL 1030 CSSIGSCVNM 1040 KTCSENTLPL 1050 KGSYIIKTSV 1060 SSSVKAVPFA 1070 NVLPEQQGPN 1080 VNVLDAVKQQ 1090 NESLPKASLY 1100 TLMPDGKQAV 1110 FFKCMMPNNT 1120 KLLKPRLVQN 1130 STYQRIQPKR 1140 PAGAPQKILL 1150 KIFNPVLSMS 1160 AVNNLSVGNS 1170 ASSFQKEIVP 1180 SKPTVHGEQK 1190 VPQSSRDALP 1200 VSVQDLMPAN 1210 EAVLSSTAAC 1220 PGSSEEPVHI 1230 SERSETRVSR 1240 SKANCTIERN 1250 FNKRKTCKNK 1260 FAKIKTRISQ 1270 DSETAFVSRN 1280 RSCKRKYIDN 1290 YQEPPRKKSA 1300 THRKCKERAN 1310 AEDVQETFGF 1320 SRPRLPKDSG 1330 RTLRLFPFNS 1340 EQLVKCPRRN 1350 QPVVVLNHPD 1360 ADAPEVERVM 1370 KTITKFNGRV 1380 LKVSLSKATI 1390 NALLKPVSIT 1400 SETTYSDFSK 1410 RHKMLKPVNS 1420 VKERFVLKLT 1430 LKKTSKNNYQ 1440 IVKTTSEDVL 1450 KSKFNCWFCG 1460 RVFDNQDVWA 1470 GHGQRHLVEA TKDWNMLE

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0006351	DNA-templated transcription
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.