Overview
| Uniprot ID | Q49A26 |
|---|
| Protein Name | Cytokine-like nuclear factor N-PAC |
|---|
| Gene Name | GLYR1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 237 |
VCYQAITKKLKICEE |
| 238 |
CYQAITKKLKICEEE |
Function
Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664)
Protein Sequence
10
MAAVSLRLGD
20
LVWGKLGRYP
30
PWPGKIVNPP
40
KDLKKPRGKK
50
CFFVKFFGTE
60
DHAWIKVEQL
70
KPYHAHKEEM
80
IKINKGKRFQ
90
QAVDAVEEFL
100
RRAKGKDQTS
110
SHNSSDDKNR
120
RNSSEERSRP
130
NSGDEKRKLS
140
LSEGKVKKNM
150
GEGKKRVSSG
160
SSERGSKSPL
170
KRAQEQSPRK
180
RGRPPKDEKD
190
LTIPESSTVK
200
GMMAGPMAAF
210
KWQPTASEPV
220
KDADPHFHHF
230
LLSQTEKPAV
240
CYQAITKKLK
250
ICEEETGSTS
260
IQAADSTAVN
270
GSITPTDKKI
280
GFLGLGLMGS
290
GIVSNLLKMG
300
HTVTVWNRTA
310
EKCDLFIQEG
320
ARLGRTPAEV
330
VSTCDITFAC
340
VSDPKAAKDL
350
VLGPSGVLQG
360
IRPGKCYVDM
370
STVDADTVTE
380
LAQVIVSRGG
390
RFLEAPVSGN
400
QQLSNDGMLV
410
ILAAGDRGLY
420
EDCSSCFQAM
430
GKTSFFLGEV
440
GNAAKMMLIV
450
NMVQGSFMAT
460
IAEGLTLAQV
470
TGQSQQTLLD
480
ILNQGQLASI
490
FLDQKCQNIL
500
QGNFKPDFYL
510
KYIQKDLRLA
520
IALGDAVNHP
530
TPMAAAANEV
540
YKRAKALDQS
550
DNDMSAVYRA
YIH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000786 |
nucleosome |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0140463 |
chromatin-protein adaptor activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0051287 |
NAD binding |
| Molecular Function |
GO:0050661 |
NADP binding |
| Molecular Function |
GO:0031491 |
nucleosome binding |
| Biological Process |
GO:0140673 |
transcription elongation-coupled chromatin remodeling |
| Biological Process |
GO:0045815 |
transcription initiation-coupled chromatin remodeling |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.