Search Results
Overview
| Uniprot ID | Q49I35 |
|---|---|
| Protein Name | Galectin-1 |
| Gene Name | LGALS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | VASNLNLKPGECLKV |
| 130 | ADGDFKIKCVAFE** |
| 19 | LKPGECLKVRGEVAP |
| 29 | GEVAPDAKSFVLNLG |
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis
Protein Sequence
10
MACGLVASNL
20
NLKPGECLKV
30
RGEVAPDAKS
40
FVLNLGKDSN
50
NLCLHFNPRF
60
DMHGDINTIV
70
CNSKDGGAWG
80
AEQRESAFPF
90
QPGSVVEVCI
100
SFGQTDLTIK
110
LPDGYEFSFP
120
NRLNLEAIEH
130
LAADGDFKIK
CVAFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0030395 | lactose binding |
| Molecular Function | GO:0043236 | laminin binding |
| Biological Process | GO:0006915 | apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.