Overview
| Uniprot ID | Q4FZT0 |
|---|
| Protein Name | Stomatin-like protein 2, mitochondrial |
|---|
| Gene Name | Stoml2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 222 |
INVAEGKKQAQILAS |
Function
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity)
Protein Sequence
10
MLARAARGTG
20
ALLLRGSVQA
30
SGRIPRRASS
40
GLPRNTVILF
50
VPQQEAWVVE
60
RMGRFHRILE
70
PGLNVLIPVL
80
DRIRYVQSLK
90
EIVINVPEQS
100
AVTLDNVTLQ
110
IDGVLYLRIM
120
DPYKASYGVE
130
DPEYAVTQLA
140
QTTMRSELGK
150
LSLDKVFRER
160
ESLNANIVDA
170
INQAADCWGI
180
RCLRYEIKDI
190
HVPPRVKESM
200
QMQVEAERRK
210
RATVLESEGT
220
RESAINVAEG
230
KKQAQILASE
240
AEKAEQINQA
250
AGEASAVLAK
260
AKAKAEAIRI
270
LAGALTQHNG
280
DAAASLTVAE
290
QYVSAFSKLA
300
KDSNTVLLPS
310
NPSDVTSMVA
320
QAMGVYGALT
330
KAPVPGAQNS
340
SEARRDVQTT
350
DTSIEELGRV
KLS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:1901612 |
cardiolipin binding |
| Molecular Function |
GO:0051020 |
GTPase binding |
| Molecular Function |
GO:0042608 |
T cell receptor binding |
| Biological Process |
GO:0035710 |
CD4-positive, alpha-beta T cell activation |
| Biological Process |
GO:0006874 |
intracellular calcium ion homeostasis |
| Biological Process |
GO:0010876 |
lipid localization |
| Biological Process |
GO:0034982 |
mitochondrial protein processing |
| Biological Process |
GO:0007005 |
mitochondrion organization |
| Biological Process |
GO:0032743 |
positive regulation of interleukin-2 production |
| Biological Process |
GO:0051259 |
protein complex oligomerization |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
| Biological Process |
GO:1990046 |
stress-induced mitochondrial fusion |
| Biological Process |
GO:0050852 |
T cell receptor signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.