Search Results
Overview
| Uniprot ID | Q4FZT2 |
|---|---|
| Protein Name | Protein phosphatase methylesterase 1 |
| Gene Name | Ppme1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 30 | GGSQSGAKMRMGPGR |
| 328 | AGVDRLDKDLTIGQM |
| 6 | **MSALEKSMHLGRL |
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity)
Protein Sequence
10
MSALEKSMHL
20
GRLPSRPPLP
30
GSGGSQSGAK
40
MRMGPGRKRD
50
FTPVPWSQYF
60
ESMEDVEVEN
70
ETGKDTFRVY
80
KSGSEGPVLL
90
LLHGGGHSAL
100
SWAVFTAAII
110
SRVQCRIVAL
120
DLRSHGETKV
130
KNSEDLSAET
140
MAKDVGNVVE
150
AMYGDLPPPV
160
MLIGHSMGGA
170
IAVHTAAANL
180
VPSLLGLCMI
190
DVVEGTAMDA
200
LNSMQNFLRG
210
RPKTFKSLEN
220
AIEWSVKSGQ
230
IRNLESARVS
240
MVGQVKQCEG
250
ITSPESSKSI
260
VEGIIEEEEE
270
DEEGSESVNK
280
RKKEDDMETK
290
KDHPYTWRIE
300
LAKTEKYWDG
310
WFRGLSNLFL
320
SCPIPKLLLL
330
AGVDRLDKDL
340
TIGQMQGKFQ
350
MQVLPQCGHA
360
VHEDAPDKVA
370
EAVATFLIRH
380
RFAEPIGGFQ
CVFPGC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051723 | protein methylesterase activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0002028 | regulation of sodium ion transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.