Search Results
Overview
| Uniprot ID | Q4FZU6 |
|---|---|
| Protein Name | Annexin A8 |
| Gene Name | Anxa8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 82 | LKSELSGKFERLIVA |
Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade
Protein Sequence
10
MAWWKAWVEQ
20
EGVSVKGSSH
30
FNPDPDAETL
40
YKAMKGIGTN
50
EQAIIDVLTK
60
RSNVQRQQIA
70
KSFKAQFGKD
80
LTETLKSELS
90
GKFERLIVAL
100
MYPPYRYEAK
110
ELHDAMKGLG
120
TKEGVIIEIL
130
ASRTKNQLRE
140
IMKAYEEDYG
150
STLEEDIQGD
160
TSGYLERILV
170
CLLQGCRDDV
180
SGFVDPGLAL
190
QDAQDLHAAG
200
EKILGTDEMK
210
FITILCTRSA
220
THLMRVFEEY
230
EKIANKSIED
240
SIKSETHGSL
250
EEAMLTVVKC
260
TRNVHSYFAE
270
RLYYAMKGAG
280
TLDGTLIRNI
290
VSRSEIDLNL
300
IKSQFQKMYG
310
KTLSSMIMGD
320
TSGYYKTALL
NLVGTDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:0007032 | endosome organization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.