Search Results
Overview
| Uniprot ID | Q4FZX5 |
|---|---|
| Protein Name | Methionine-R-sulfoxide reductase B2, mitochondrial |
| Gene Name | Msrb2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 49 | SKADWQKKLTPEQFY |
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance
Protein Sequence
10
MARLLRALRG
20
LPWLEAPGRA
30
RGCAGSGRGD
40
TGSLIKSKLS
50
LSKADWQKKL
60
TPEQFYVTRE
70
KGTEAPFSGM
80
YLKNKETGMY
90
HCVCCDSPLF
100
SSEKKYCSGT
110
GWPSFSEAHG
120
TKGSDESHTG
130
ILRRLDTSLG
140
CPRMEVVCKQ
150
CEAHLGHVFP
160
DGPDPTGQRF
170
CINSVALKFK
PSKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0033745 | L-methionine (R)-S-oxide reductase activity |
| Molecular Function | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0030091 | protein repair |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.