Search Results
Overview
| Uniprot ID | Q4FZY0 |
|---|---|
| Protein Name | EF-hand domain-containing protein D2 |
| Gene Name | Efhd2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 187 | DVSTEGVKGAKNFFE |
| 190 | TEGVKGAKNFFEAKV |
| 196 | AKNFFEAKVQAINVS |
| 232 | KQRKAAFKELQSTFK |
| 9 | ATDELASKLSRRLQM |
Function
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance
Protein Sequence
10
MATDELASKL
20
SRRLQMEDEG
30
GEATEQPGLN
40
GAAAAAAEAP
50
DETAQALGSA
60
DDELSAKLLR
70
RADLNQGIGE
80
PQSPSRRVFN
90
PYTEFKEFSR
100
KQIKDMEKMF
110
KQYDAGKDGF
120
IDLMELKLMM
130
EKLGAPQTHL
140
GLKSMIQEVD
150
EDFDSKLSFR
160
EFLLIFRKAA
170
AGELQEDSGL
180
HVLARLSEID
190
VSTEGVKGAK
200
NFFEAKVQAI
210
NVSSRFEEEI
220
KAEQEERKKQ
230
AEEVKQRKAA
FKELQSTFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045121 | membrane raft |
| Molecular Function | GO:0005509 | calcium ion binding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.