Overview
| Uniprot ID | Q4G0F5 |
|---|
| Protein Name | Vacuolar protein sorting-associated protein 26B |
|---|
| Gene Name | VPS26B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 301 |
RKGDIVRKSMSHQAA |
Function
Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity)
Protein Sequence
10
MSFFGFGQSV
20
EVEILLNDAE
30
SRKRAEHKTE
40
DGKKEKYFLF
50
YDGETVSGKV
60
SLALKNPNKR
70
LEHQGIKIEF
80
IGQIELYYDR
90
GNHHEFVSLV
100
KDLARPGEIT
110
QSQAFDFEFT
120
HVEKPYESYT
130
GQNVKLRYFL
140
RATISRRLND
150
VVKEMDIVVH
160
TLSTYPELNS
170
SIKMEVGIED
180
CLHIEFEYNK
190
SKYHLKDVIV
200
GKIYFLLVRI
210
KIKHMEIDII
220
KRETTGTGPN
230
VYHENDTIAK
240
YEIMDGAPVR
250
GESIPIRLFL
260
AGYELTPTMR
270
DINKKFSVRY
280
YLNLVLIDEE
290
ERRYFKQQEV
300
VLWRKGDIVR
310
KSMSHQAAIA
320
SQRFEGTTSL
330
GEVRTPSQLS
DNNCRQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005770 |
late endosome |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0098842 |
postsynaptic early endosome |
| Cellular Component |
GO:0098837 |
postsynaptic recycling endosome |
| Cellular Component |
GO:0030904 |
retromer complex |
| Cellular Component |
GO:0030906 |
retromer, cargo-selective complex |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0016241 |
regulation of macroautophagy |
| Biological Process |
GO:0098696 |
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.